Chapter 18

Distribution

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Student Objectives for this Chapter

Drug distribution means the reversible transfer of drug from one location to another within the body. Once a drug has entered the vascular system it becomes distributed throughout the various tissues and body fluids in a pattern that reflects the physiochemical nature of the drug and the ease with which it penetrates different membranes. The ONE COMPARTMENT model assumes rapid distribution but it does not preclude extensive distribution into various tissues.

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