One Compartment Oral
Chapter 8 Problem 1

Plot of Cp versus Time after Oral Administration
One Compartment Model



Consider a drug with the parameter values in healthy subjects: F = 0.1; V = 766 L; kel = 0.105 hr-1; ka = 3.0 hr-1; CL = 74 L/hr. Plot a concentration versus time curve after an oral dose of 192 mg. Contrast this with the results obtained with the same dose given to a patient with severe cirrhosis. Use the parameter values: F = 1.0; V = 777 L; kel = 0.080 hr-1; ka = 3.0 hr-1; CL = 62 L/hr. Pentikainen et al., 1978 Add a second line with these parameter values using the Plot Line button.

  Healthy Subject Severe Cirrhosis
F 0.1 1.0
ka (hr-1) 3.0 3.0
kel (hr-1) 0.105 0.080
CL (L/hr) 80.4 62.2
V (L) 766 777

References


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