One Compartment Oral
Chapter 8 Problem 2

Plot of Cp versus Time after Oral Administration
One Compartment Model



Consider a drug with the parameter values in healthy subjects: F = 0.30; V = 290 L; kel = 0.173 hr-1; ka = 3.0 hr-1; CL = 860 ml/min. Plot a concentration versus time curve after an oral dose of 80 mg. Contrast this with the results obtained with the same dose given to a patient with severe cirrhosis. Use the parameter values: F = 0.42; V = 380 L; kel = 0.063 hr-1; ka = 3.0 hr-1; CL = 580 ml/min. Wood et al., 1978. Add a second line with these parameter values using the Plot Line button.

  Healthy Subject Severe Cirrhosis
F 0.3 0.42
ka (hr-1) 3.0 3.0
kel (hr-1) 0.173 0.063
CL (L/hr) 50.2 23.9
V (L) 290 380

References


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