One Compartment Oral
Chapter 8 Problem 3

Plot of Cp versus Time after Oral Administration
One Compartment Model



Consider a drug with the parameter values in original product: F = 0.30; V = 180 L; kel = 0.023 hr-1; ka = 5.0 hr-1; CL = 69 ml/min. Plot a concentration versus time curve after an oral dose of 500 mcg (0.5 mg). Contrast this with the results obtained with the same dose but with the new formulation. Use the parameter values: F = 0.75; V = 180 L; kel = 0.023 hr-1; ka = 5.0 hr-1; CL = 69 ml/min. Danon et al., 1977. Add a second line with these parameter values using the Plot Line button.

  Original Product New Formulation
F 0.3 0.75
ka (hr-1) 5.0 5.0
kel (hr-1) 0.023 0.023
CL (L/hr) 4.14 4.14
V (L) 180 180

References


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