Linear Plot of Cp versus Time after Oral Administration

First try simulating concentration versus time after an Oral Dose: Dose = 250 mg; kel = 0.10 hr-1; ks = 0.12 hr-1; ke = 1.4 hr-1; ki = 2.1 hr-1; V = 24 L. This ke value represents a stomach emptying time of 30 minutes (0.5 hr). Compare this line with lines generated with slower stomach emptying, that is, lower ke values. Plot Cpmax (or tmax) versus stomach emptying half-life. Add additional lines with the Plot Line button.

Figure 11.3.1 One Compartment Model with Absorption from Stomach and Intestine

The equations for this model after Oral Absorption was developed using Laplace transforms. References Heading, R.C., Nimmo, J., Prescott, L.F. and Tothill, P. 1973. The dependence of paracetamol absorption on the rate of gastric emptying, Br. J. Pharmacol., 47, 415-421

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