A dose of 100 mg is given over 1 hour, here assumed to be bolus dose. Time the required for the concentration drop to 10 mg.
Concentration at 2 hour is 18.6 mg/L
Concentration at 12 hour is 13.1 mg/L
First calculate the elimination rate constant.
Back calculating to time zero gives the concentration at time zero (immediately after the dose).
We can now calculate the time when the concentration is expected to fall to 10 mg/L.
We can now calculate the apparent volume of distribution.
The last step is calculate dose required to jump the concentration from 10 mg/L to 25 mg/L. An increase of 15 mg/L.
Investigate the effect of changing the Dose, Dosing interval (tau), elimination rate constant (kel), clearance (CL) and apparent volume of distribution (V) on the plot of plasma concentration (Cp) versus time. Explore the model by changing the parameter(s). Add additional lines with different parameter values using the Plot Line button.
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