|Day/Time (hhmm)||Dose (mg/hr)||Sample (mg/L)|
|Day 1 at 0700||600 over 1 hr|
|Day 1 at 1900||600 over 1 hr|
|Day 2 at 0630||5.6|
|Day 2 at 0700||600 over 1 hr|
|Day 2 at 0930||16|
|Day 2 at 1845||6.3|
Calculate the kel, V, Clearance and t1/2 for this drug in this patient.
Hint: Sketch the expected concentration versus time curve for the second day.
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Equation 6.2.1 An equation for determining kel from two data points
Remember drug concentration at future times can be determined using Equation 6.2.2.
Equation 6.2.2 Concentration at another time
The concentration due to the next infusion can be calculated from Equation 6.2.3.
Equation 6.2.3 Concentration versus time, post infusion
Equation 6.2.4 Apparent volume of distribution
Problem by Dr Vincent Dennis, programming by Dr David Bourne.