IV Infusion - Example Calculations

During an IV Infusion - Linear One Compartment Model

Question 1. Calculate the drug concentration 18 hours after a continuous IV infusion of 10 mg/hr has been administered to a patient. Assume a one compartment pharmacokinetic model. The V and t1/2 values for this drug are 48.2 L and 3 hr respectively.
Question 2. Calculate the infusion rate required to achieve a drug concentration of 10 mg/L at 6 hours after a continuous IV infusion has been started. Assume a one compartment pharmacokinetic model. The kel and V values for this drug are 0.209 hr-1 and 42.1 L respectively.
Question 3. Calculate the steady state drug concentration after a continuous IV infusion of 10 mg/hr has been administered to the patient. Assume a one compartment pharmacokinetic model. The kel and V values for this drug are 0.276 hr-1 and 30.4 L respectively.
Question 4. Calculate the infusion rate required to achieve a steady state drug concentration of 0.5 mg/L. Assume a one compartment pharmacokinetic model. The V and total body clearance values for this drug are 39.4 L and 6.7 L/hr respectively.


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Some Equations:

Cp during an IV infusion

Equation 15.1.1 Drug Concentration during an IV Infusion

Cp after a continuous IV Infusion

Equation 15.1.2 Steady State Drug Concentration after an IV Infusion


Last update: Sun 14 Apr 2019 08:16:58 pm
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