IV Infusion - Example Calculations
During an IV Infusion - Linear One Compartment Model
Calculate the drug concentration 24 hours after a continuous IV infusion of 10 mg/hr has been administered to a patient. Assume a one compartment pharmacokinetic model.
The kel and V values for this drug are 0.202 hr-1 and 23.9 L respectively.
Calculate the infusion rate required to achieve a drug concentration of 2 mg/L at 6 hours after a continuous IV infusion has been started. Assume a one compartment pharmacokinetic model.
The V and t1/2 values for this drug are 42 L and 2.3 hr respectively.
Calculate the steady state drug concentration after a continuous IV infusion of 75 mg/hr has been administered to the patient. Assume a one compartment pharmacokinetic model.
The V and total body clearance values for this drug are 27.8 L and 8.2 L/hr respectively.
Calculate the infusion rate required to achieve a steady state drug concentration of 18 mg/L. Assume a one compartment pharmacokinetic model.
The V and t1/2 values for this drug are 54 L and 19 hr respectively.
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Equation 15.1.1 Drug Concentration during an IV Infusion
Equation 15.1.2 Steady State Drug Concentration after an IV Infusion
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