IV Infusion - Example Calculations

After an IV Infusion - Linear One Compartment Model

Question 1. Calculate the infusion rate required to maintain a desired drug concentration of 6 mg/L and an IV bolus dose to achieve that concentration rapidly. Assume a one compartment pharmacokinetic model. The kel and V values for this drug are 0.27 hr-1 and 41.9 L respectively.
Question 2. Calculate the fast infusion rate (over 90 min) required to achieve a desired drug concentration of 40 mg/L and a slow IV infusion rate to maintain that concentration. Assume a one compartment pharmacokinetic model. The kel and V values for this drug are 0.176 hr-1 and 46.9 L respectively.
Question 3. A drug has been given at an infusion rate of 6 mg/hr for 30 min. Two drug concentration values determined at 1.25 hr and 15 hr after the start of the infusion were 0.106 and 0.017 mg/L, respectively. Assuming a one compartment model applies for this drug estimate the elimination rate constant, elimination half-life, apparent volume of distribution and the total body clearance for the drug.

NOTE: Clicking the button above
will prevent you getting credit for this problem

To get credit for this problem print this page, work the problem and

You will have one chance to submit your answers for this problem [# 481519573]. You can try more than once with different data to improve your grade.


The Equations:

Cp versus time after an IV infusion - CL

Equation 15.2.1 Drug Concentration after an IV Infusion


Last update: Mon 9 Sep 2024 03:39:29 pm
Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available

Copyright © 2002-2024 David Bourne (david@boomer.org)