Determine Parameters from Post IV Infusion Data

IV Infusion - Linear One Compartment

A drug was administered by IV infusion of 75 mg/hr for 15 min to healthy volunteer. Seven blood samples were collected at 2, 3, 4, 6, 8, 10, and 12 hours after the start of the infusion. Plasma was separated from each blood sample and analyzed for drug concentration. The collected data are shown in the table below.

Time (hr) Cp (mg/L)
2 0.396
3 0.292
4 0.206
6 0.112
8 0.059
10 0.031
12 0.017

Estimate kel, t1/2, V, and Cl.


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