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Calculation of Drug Concentration

Non-Uniform Multiple Oral Dose Regimen

A patient is started on a drug at an oral dose of 400 mg at time zero, 250 mg at 7 hours and 250 mg at 14 hours (makes no sense but a nice random regimen :- all times are from time zero). Using the data shown in the table below calculate the drug concentration at 24 hr after the first dose time. Assume a one compartment linear model applies to this drug in this concentration range.

Concentration versus Time after a Single 100 mg dose

Time (hr) Concentration (mg/L)

0 0

1 3.29

2 3.17

3 2.74

4 2.33

5 1.99

6 1.69

7 1.44

8 1.22

9 1.04

10 0.883

11 0.751

12 0.639

13 0.543

14 0.462

15 0.393

16 0.334

17 0.284

18 0.242

19 0.206

20 0.175

21 0.149

22 0.126

23 0.108

24 0.0914

Concentration versus Time after a Single 100 mg dose
Time (hr)	Concentration (mg/L)
0	0
1	3.29
2	3.17
3	2.74
4	2.33
5	1.99
6	1.69
7	1.44
8	1.22
9	1.04
10	0.883
11	0.751
12	0.639
13	0.543
14	0.462
15	0.393
16	0.334
17	0.284
18	0.242
19	0.206
20	0.175
21	0.149
22	0.126
23	0.108
24	0.0914

The equation:

Cp after non uniform multiple dose regimen

Equation 15.4.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)

Last update: Sat 27 Jul 2024 08:10:08 pm

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