Calculation of Drug Concentration

Non-Uniform Multiple Oral Dose Regimen

A patient is started on a drug at an oral dose of 250 mg at time zero, 300 mg at 5 hours and 250 mg at 7 hours (makes no sense but a nice random regimen :- all times are from time zero). Using the data shown in the table below calculate the drug concentration at 24 hr after the first dose time. Assume a one compartment linear model applies to this drug in this concentration range.

Concentration versus Time after a Single 100 mg dose

Time (hr) Concentration (mg/L)

0 0

1 4.86

2 4.09

3 3.26

4 2.58

5 2.05

6 1.62

7 1.29

8 1.02

9 0.809

10 0.642

11 0.509

12 0.404

13 0.32

14 0.254

15 0.201

16 0.16

17 0.127

18 0.1

19 0.0795

20 0.0631

21 0.05

22 0.0397

23 0.0314

24 0.0249

Concentration versus Time after a Single 100 mg dose
Time (hr)	Concentration (mg/L)
0	0
1	4.86
2	4.09
3	3.26
4	2.58
5	2.05
6	1.62
7	1.29
8	1.02
9	0.809
10	0.642
11	0.509
12	0.404
13	0.32
14	0.254
15	0.201
16	0.16
17	0.127
18	0.1
19	0.0795
20	0.0631
21	0.05
22	0.0397
23	0.0314
24	0.0249

The equation:

Cp after non uniform multiple dose regimen

Equation 15.4.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)

Last update: Sat 28 Nov 2015 04:52:06 pm