Calculation of Drug Concentration

Non-Uniform Multiple Oral Dose Regimen

A patient is started on a drug at an oral dose of 125 mg at time zero, 150 mg at 5 hours and 150 mg at 12 hours (makes no sense but a nice random regimen :- all times are from time zero). Using the data shown in the table below calculate the drug concentration at 24 hr after the first dose time. Assume a one compartment linear model applies to this drug in this concentration range.

Concentration versus Time after a Single 100 mg dose

Time (hr) Concentration (mg/L)

0 0

1 1.59

2 1.59

3 1.36

4 1.14

5 0.941

6 0.779

7 0.644

8 0.532

9 0.44

10 0.364

11 0.301

12 0.249

13 0.206

14 0.17

15 0.141

16 0.116

17 0.0963

18 0.0796

19 0.0659

20 0.0545

21 0.045

22 0.0372

23 0.0308

24 0.0255

Concentration versus Time after a Single 100 mg dose
Time (hr)	Concentration (mg/L)
0	0
1	1.59
2	1.59
3	1.36
4	1.14
5	0.941
6	0.779
7	0.644
8	0.532
9	0.44
10	0.364
11	0.301
12	0.249
13	0.206
14	0.17
15	0.141
16	0.116
17	0.0963
18	0.0796
19	0.0659
20	0.0545
21	0.045
22	0.0372
23	0.0308
24	0.0255

The equation:

Cp after non uniform multiple dose regimen

Equation 15.4.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)

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