1970111100

Calculation of Drug Concentration

Non-Uniform Multiple Oral Dose Regimen

A patient is started on a drug at an oral dose of 125 mg at time zero, 400 mg at 2 hours and 500 mg at 4 hours (makes no sense but a nice random regimen :- all times are from time zero). Using the data shown in the table below calculate the drug concentration at 24 hr after the first dose time. Assume a one compartment linear model applies to this drug in this concentration range.

Concentration versus Time after a Single 100 mg dose
Time (hr) Concentration (mg/L)
0 0
1 5.75
2 5.73
3 4.75
4 3.77
5 2.96
6 2.32
7 1.81
8 1.42
9 1.11
10 0.866
11 0.677
12 0.53
13 0.414
14 0.324
15 0.253
16 0.198
17 0.155
18 0.121
19 0.0946
20 0.074
21 0.0579
22 0.0452
23 0.0354
24 0.0277


The equation:

Cp after non uniform multiple dose regimen

Equation 15.4.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)


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