691703519
Calculation of Drug Concentration
Non-Uniform Multiple Oral Dose Regimen
A patient is started on a drug at an oral dose of 250 mg at time zero, 50 mg at 3 hours and 150 mg at 7 hours (makes no sense but a nice random regimen :- all times are from time zero). Using the data shown in the table below calculate the drug concentration at 24 hr after the first dose time. Assume a one compartment linear model applies to this drug in this concentration range.
|
Concentration versus Time after a Single 100 mg dose
|
| Time (hr) |
Concentration (mg/L) |
|
0 |
0 |
|
1 |
3.36 |
|
2 |
2.94 |
|
3 |
2.22 |
|
4 |
1.64 |
|
5 |
1.2 |
|
6 |
0.878 |
|
7 |
0.643 |
|
8 |
0.471 |
|
9 |
0.345 |
|
10 |
0.252 |
|
11 |
0.185 |
|
12 |
0.135 |
|
13 |
0.0989 |
|
14 |
0.0724 |
|
15 |
0.053 |
|
16 |
0.0388 |
|
17 |
0.0284 |
|
18 |
0.0208 |
|
19 |
0.0152 |
|
20 |
0.0111 |
|
21 |
0.00815 |
|
22 |
0.00597 |
|
23 |
0.00437 |
|
24 |
0.0032 |
The equation:
Equation 15.4.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)
Last update: Sat 27 Jul 2024 08:10:08 pm
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