Calculation of Drug Concentration

Non-Uniform Multiple Oral Dose Regimen

A patient is started on a drug at an oral dose of 100 mg at time zero, 125 mg at 7 hours and 125 mg at 12 hours (makes no sense but a nice random regimen :- all times are from time zero). Using the data shown in the table below calculate the drug concentration at 24 hr after the first dose time. Assume a one compartment linear model applies to this drug in this concentration range.

Concentration versus Time after a Single 100 mg dose

Time (hr) Concentration (mg/L)

0 0

1 7.5

2 6.64

3 5.24

4 4.07

5 3.15

6 2.44

7 1.89

8 1.46

9 1.13

10 0.875

11 0.678

12 0.525

13 0.406

14 0.314

15 0.243

16 0.188

17 0.146

18 0.113

19 0.0874

20 0.0677

21 0.0524

22 0.0406

23 0.0314

24 0.0243

Concentration versus Time after a Single 100 mg dose
Time (hr)	Concentration (mg/L)
0	0
1	7.5
2	6.64
3	5.24
4	4.07
5	3.15
6	2.44
7	1.89
8	1.46
9	1.13
10	0.875
11	0.678
12	0.525
13	0.406
14	0.314
15	0.243
16	0.188
17	0.146
18	0.113
19	0.0874
20	0.0677
21	0.0524
22	0.0406
23	0.0314
24	0.0243

The equation:

Cp after non uniform multiple dose regimen

Equation 15.4.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)

Last update: Sat 27 Jul 2024 08:10:08 pm

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