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Calculation of Drug Concentration

Non-Uniform Multiple Oral Dose Regimen

A patient is started on a drug at an oral dose of 150 mg at time zero, 100 mg at 2 hours and 500 mg at 6 hours (makes no sense but a nice random regimen :- all times are from time zero). Using the data shown in the table below calculate the drug concentration at 24 hr after the first dose time. Assume a one compartment linear model applies to this drug in this concentration range.

Concentration versus Time after a Single 100 mg dose

Time (hr) Concentration (mg/L)

0 0

1 6.2

2 6.06

3 5.23

4 4.42

5 3.73

6 3.15

7 2.66

8 2.24

9 1.89

10 1.6

11 1.35

12 1.14

13 0.959

14 0.809

15 0.682

16 0.576

17 0.486

18 0.41

19 0.346

20 0.292

21 0.246

22 0.208

23 0.175

24 0.148

Concentration versus Time after a Single 100 mg dose
Time (hr)	Concentration (mg/L)
0	0
1	6.2
2	6.06
3	5.23
4	4.42
5	3.73
6	3.15
7	2.66
8	2.24
9	1.89
10	1.6
11	1.35
12	1.14
13	0.959
14	0.809
15	0.682
16	0.576
17	0.486
18	0.41
19	0.346
20	0.292
21	0.246
22	0.208
23	0.175
24	0.148

The equation:

Cp after non uniform multiple dose regimen

Equation 15.4.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)

Last update: Sat 27 Jul 2024 08:10:08 pm

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