2691402514

Calculation of Drug Concentration

Non-Uniform Multiple Oral Dose Regimen

A patient is started on a drug at an oral dose of 150 mg at time zero, 150 mg at 7 hours and 400 mg at 9 hours (makes no sense but a nice random regimen :- all times are from time zero). Using the data shown in the table below calculate the drug concentration at 24 hr after the first dose time. Assume a one compartment linear model applies to this drug in this concentration range.

Concentration versus Time after a Single 100 mg dose
Time (hr) Concentration (mg/L)
0 0
1 3.8
2 3.04
3 2.25
4 1.66
5 1.22
6 0.896
7 0.659
8 0.485
9 0.357
10 0.262
11 0.193
12 0.142
13 0.104
14 0.0769
15 0.0565
16 0.0416
17 0.0306
18 0.0225
19 0.0166
20 0.0122
21 0.00896
22 0.00659
23 0.00485
24 0.00357


The equation:

Cp after non uniform multiple dose regimen

Equation 15.4.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)


Last update: Sat 28 Nov 2015 04:52:06 pm
Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available

Copyright © 2002-2020 David Bourne (david@boomer.org)