Calculation of Drug Concentration

Non-Uniform Multiple Oral Dose Regimen

A patient is started on a drug at an oral dose of 125 mg at time zero, 150 mg at 7 hours and 250 mg at 14 hours (makes no sense but a nice random regimen :- all times are from time zero). Using the data shown in the table below calculate the drug concentration at 24 hr after the first dose time. Assume a one compartment linear model applies to this drug in this concentration range.

Concentration versus Time after a Single 100 mg dose

Time (hr) Concentration (mg/L)

0 0

1 1.24

2 1.25

3 0.994

4 0.73

5 0.52

6 0.366

7 0.256

8 0.179

9 0.125

10 0.0871

11 0.0607

12 0.0423

13 0.0295

14 0.0206

15 0.0143

16 0.00998

17 0.00696

18 0.00485

19 0.00338

20 0.00236

21 0.00164

22 0.00114

23 0.000798

24 0.000556

Concentration versus Time after a Single 100 mg dose
Time (hr)	Concentration (mg/L)
0	0
1	1.24
2	1.25
3	0.994
4	0.73
5	0.52
6	0.366
7	0.256
8	0.179
9	0.125
10	0.0871
11	0.0607
12	0.0423
13	0.0295
14	0.0206
15	0.0143
16	0.00998
17	0.00696
18	0.00485
19	0.00338
20	0.00236
21	0.00164
22	0.00114
23	0.000798
24	0.000556

The equation:

Cp after non uniform multiple dose regimen

Equation 15.4.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)

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