Calculation of Drug Concentration

Non-Uniform Multiple Oral Dose Regimen

A patient is started on a drug at an oral dose of 150 mg at time zero, 150 mg at 7 hours and 400 mg at 9 hours (makes no sense but a nice random regimen :- all times are from time zero). Using the data shown in the table below calculate the drug concentration at 24 hr after the first dose time. Assume a one compartment linear model applies to this drug in this concentration range.

Concentration versus Time after a Single 100 mg dose

Time (hr) Concentration (mg/L)

0 0

1 3.8

2 3.04

3 2.25

4 1.66

5 1.22

6 0.896

7 0.659

8 0.485

9 0.357

10 0.262

11 0.193

12 0.142

13 0.104

14 0.0769

15 0.0565

16 0.0416

17 0.0306

18 0.0225

19 0.0166

20 0.0122

21 0.00896

22 0.00659

23 0.00485

24 0.00357

Concentration versus Time after a Single 100 mg dose
Time (hr)	Concentration (mg/L)
0	0
1	3.8
2	3.04
3	2.25
4	1.66
5	1.22
6	0.896
7	0.659
8	0.485
9	0.357
10	0.262
11	0.193
12	0.142
13	0.104
14	0.0769
15	0.0565
16	0.0416
17	0.0306
18	0.0225
19	0.0166
20	0.0122
21	0.00896
22	0.00659
23	0.00485
24	0.00357

The equation:

Cp after non uniform multiple dose regimen

Equation 15.4.1 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)

Last update: Sat 28 Nov 2015 04:52:06 pm

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