Bioavailability Calculations - Determination of F

Question 1. The AUC calculated after an oral tablet (A) of 125 mg was 76 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 33.69 L and 0.227 hr-1. After an oral capsule dose (B) of 75 mg the calculated AUC was 137.7 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 33.62 L and 0.2198 hr-1. Calculate the relative bioavailability of the tablet A with respect to the capsule B.
Question 2. The AUC calculated after an oral tablet (A) of 200 mg was 143.6 mg.hr/L. After an oral capsule dose (B) of 150 mg the calculated AUC was 72.2 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.57 calculate the absolute bioavailability of the tablet dosage form.
Question 3. The total amount excreted into urine as unchanged drug after an oral tablet (A) of 75 mg was 56.7 mg. After an oral capsule dose (B) of 50 mg the U was 38.6 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.92 calculate the absolute bioavailability of the tablet dosage form.

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Some Equations:

F calculated from AUC ratio

Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values

F calculated from U(inf) ratio

Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U Values


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