# Bioavailability Calculations - Determination of F

Question 1.
The AUC calculated after an oral tablet (A) of **250 mg** was 70.5 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 42.49 L and 0.1763 hr^{-1}. After an oral capsule dose (B) of **75 mg** the calculated AUC was 115.5 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 43.02 L and 0.1704 hr^{-1}. Calculate the relative bioavailability of the tablet A with respect to the capsule B.

Question 2.
The AUC calculated after an oral tablet (A) of **250 mg** was 143.6 mg.hr/L. After an oral capsule dose (B) of **100 mg** the calculated AUC was 39.6 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations.
If the absolute bioavailability of the oral capsule is determined to be 0.69 calculate the absolute bioavailability of the tablet dosage form.

Question 3.
The total amount excreted into urine as unchanged drug after an oral tablet (A) of **250 mg** was 218.2 mg. After an oral capsule dose (B) of **50 mg** the U^{∞} was 30.4 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations.
If the absolute bioavailability of the oral capsule is determined to be 0.69 calculate the absolute bioavailability of the tablet dosage form.

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**Some Equations:**

**Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values**

**Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U**^{∞} Values

Last update: Sat 27 Jul 2024 08:10:09 pm

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