# Bioavailability Calculations - Determination of F

Question 1. The AUC calculated after an oral tablet (A) of 25 mg was 72.4 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 58.26 L and 0.2416 hr-1. After an oral capsule dose (B) of 25 mg the calculated AUC was 108.8 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 55.2 L and 0.2263 hr-1. Calculate the relative bioavailability of the tablet A with respect to the capsule B.
Question 2. The AUC calculated after an oral tablet (A) of 200 mg was 149.4 mg.hr/L. After an oral capsule dose (B) of 250 mg the calculated AUC was 143.8 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.77 calculate the absolute bioavailability of the tablet dosage form.
Question 3. The total amount excreted into urine as unchanged drug after an oral tablet (A) of 100 mg was 85.8 mg. After an oral capsule dose (B) of 25 mg the U was 17.1 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.78 calculate the absolute bioavailability of the tablet dosage form.

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Some Equations: Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U Values

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