# Bioavailability Calculations - Determination of F

Question 1.
The AUC calculated after an oral tablet (A) of **50 mg** was 85.5 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 32.2 L and 0.1401 hr^{-1}. After an oral capsule dose (B) of **250 mg** the calculated AUC was 73.7 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 34.96 L and 0.134 hr^{-1}. Calculate the relative bioavailability of the tablet A with respect to the capsule B.

Question 2.
The AUC calculated after an oral tablet (A) of **50 mg** was 71.7 mg.hr/L. After an oral capsule dose (B) of **250 mg** the calculated AUC was 321 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations.
If the absolute bioavailability of the oral capsule is determined to be 0.77 calculate the absolute bioavailability of the tablet dosage form.

Question 3.
The total amount excreted into urine as unchanged drug after an oral tablet (A) of **200 mg** was 119.9 mg. After an oral capsule dose (B) of **250 mg** the U^{∞} was 180.7 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations.
If the absolute bioavailability of the oral capsule is determined to be 0.88 calculate the absolute bioavailability of the tablet dosage form.

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**Some Equations:**

**Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values**

**Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U**^{∞} Values

Last update: Sat 31 Aug 2019 10:12:25 pm

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