# Bioavailability Calculations - Determination of F

Question 1. The AUC calculated after an oral tablet (A) of 250 mg was 88.3 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 26 L and 0.2447 hr-1. After an oral capsule dose (B) of 250 mg the calculated AUC was 136.1 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 28.36 L and 0.2345 hr-1. Calculate the relative bioavailability of the tablet A with respect to the capsule B.
Question 2. The AUC calculated after an oral tablet (A) of 100 mg was 109.7 mg.hr/L. After an oral capsule dose (B) of 100 mg the calculated AUC was 123.2 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.82 calculate the absolute bioavailability of the tablet dosage form.
Question 3. The total amount excreted into urine as unchanged drug after an oral tablet (A) of 150 mg was 94.9 mg. After an oral capsule dose (B) of 200 mg the U was 150.3 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.95 calculate the absolute bioavailability of the tablet dosage form.

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Some Equations: Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U Values

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