Bioavailability Calculations - Determination of F

Question 1. The AUC calculated after an oral tablet (A) of 75 mg was 75.8 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 56.96 L and 0.2809 hr-1. After an oral capsule dose (B) of 250 mg the calculated AUC was 50 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 58.94 L and 0.2644 hr-1. Calculate the relative bioavailability of the tablet A with respect to the capsule B.
Question 2. The AUC calculated after an oral tablet (A) of 100 mg was 140.2 mg.hr/L. After an oral capsule dose (B) of 125 mg the calculated AUC was 229.6 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.93 calculate the absolute bioavailability of the tablet dosage form.
Question 3. The total amount excreted into urine as unchanged drug after an oral tablet (A) of 100 mg was 58.1 mg. After an oral capsule dose (B) of 75 mg the U was 43.6 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.76 calculate the absolute bioavailability of the tablet dosage form.

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Some Equations:

F calculated from AUC ratio

Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values

F calculated from U(inf) ratio

Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U Values


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