# Bioavailability Calculations - Determination of F

Question 1.
The AUC calculated after an oral tablet (A) of **200 mg** was 95.3 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 34.01 L and 0.1172 hr^{-1}. After an oral capsule dose (B) of **150 mg** the calculated AUC was 140.5 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 34.64 L and 0.1257 hr^{-1}. Calculate the relative bioavailability of the tablet A with respect to the capsule B.

Question 2.
The AUC calculated after an oral tablet (A) of **200 mg** was 73.8 mg.hr/L. After an oral capsule dose (B) of **100 mg** the calculated AUC was 36.4 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations.
If the absolute bioavailability of the oral capsule is determined to be 0.72 calculate the absolute bioavailability of the tablet dosage form.

Question 3.
The total amount excreted into urine as unchanged drug after an oral tablet (A) of **200 mg** was 183.4 mg. After an oral capsule dose (B) of **100 mg** the U^{∞} was 81.6 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations.
If the absolute bioavailability of the oral capsule is determined to be 0.89 calculate the absolute bioavailability of the tablet dosage form.

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**Some Equations:**

**Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values**

**Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U**^{∞} Values

Last update: Sat 20 Apr 2019 07:39:40 pm

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