Bioavailability Calculations - Determination of F

Question 1. The AUC calculated after an oral tablet (A) of 150 mg was 100.4 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 20 L and 0.2464 hr^-1. After an oral capsule dose (B) of 200 mg the calculated AUC was 103.7 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 22.61 L and 0.2232 hr^-1. Calculate the relative bioavailability of the tablet A with respect to the capsule B.

Question 2. The AUC calculated after an oral tablet (A) of 200 mg was 135.8 mg.hr/L. After an oral capsule dose (B) of 100 mg the calculated AUC was 72.1 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.85 calculate the absolute bioavailability of the tablet dosage form.

Question 3. The total amount excreted into urine as unchanged drug after an oral tablet (A) of 125 mg was 68.5 mg. After an oral capsule dose (B) of 150 mg the U^∞ was 102.2 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.87 calculate the absolute bioavailability of the tablet dosage form.

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Some Equations:

Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values

Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U^∞ Values

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