Bioavailability Calculations - Determination of F

Question 1. The AUC calculated after an oral tablet (A) of 200 mg was 93.8 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 25.17 L and 0.2454 hr-1. After an oral capsule dose (B) of 200 mg the calculated AUC was 80.9 mg.hr/L. The apparent volume of distribution and elimination rate constant estimated after this dose was 22.19 L and 0.2218 hr-1. Calculate the relative bioavailability of the tablet A with respect to the capsule B.
Question 2. The AUC calculated after an oral tablet (A) of 200 mg was 70.3 mg.hr/L. After an oral capsule dose (B) of 50 mg the calculated AUC was 15.1 mg.hr/L. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the kel and V values are unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.85 calculate the absolute bioavailability of the tablet dosage form.
Question 3. The total amount excreted into urine as unchanged drug after an oral tablet (A) of 250 mg was 154.5 mg. After an oral capsule dose (B) of 25 mg the U was 16.4 mg. Calculate the relative bioavailability of the tablet A with respect to the capsule B. Assume that the fe value is unchanged between dose administrations. If the absolute bioavailability of the oral capsule is determined to be 0.88 calculate the absolute bioavailability of the tablet dosage form.

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Some Equations:

F calculated from AUC ratio

Equation 18.3.1 Bioavailability, F, Calculated as a Ratio of AUC Values

F calculated from U(inf) ratio

Equation 18.3.2 Bioavailability, F, Calculated as a Ratio of U Values


Last update: Sat 20 Apr 2019 07:39:40 pm
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