## Simulation of Drug ResponseMultiple DoseTwo Compartment Model

A patient (73.4 kg) is to receive the muscle relaxant pancuronium bromide by IV bolus to produce effective muscle relaxation (> 85%). For this patient use pharmacokinetic parameters value of A', B', α and β of 7.87 Kg/L, 2.5 Kg/L, 0.0583 min-1 and 0.00566 min-1, respectively. The pharmacological parameters ke0, CssEC50% and gamma for this patient are 0.14 min-1, 0.217 mg/L and 4.1, respectively. Martindale, The Extra Pharmacopoeia, 30th ed., Pharmaceutical Press, p 1206-7 suggests an initial dose of 40 to 100 µg per kg body weight IV with a supplemental injection of 10 to 20 µg per kg body weight with significant alteration in the presence of renal or liver disease. [Note: If dose is in mg units of A (and B) become Kg/L x mg / Kg = mg/L].

 Parameter Your answers First Bolus Dose mg Second Bolus Dose mg at min Third Bolus Dose mg at min

Enter your regimen in the table and

Figure 23.1.1 Two Compartment Model Illustrating a Response Compartment

## Some Equations

Equation 23.1.1 Drug Concentration in Plasma versus Time

Equation 23.1.2 "Steady State" Drug Concentration in Plasma versus Time
Effectively Mimicking Drug "Concentration" in the Receptor Compartment

Equation 23.1.3 Muscle Relaxant Effect (percent paralysis) versus Concentration, Cpss, the Hill Equation

Parameters and equations from Tovey, C., Stephens, I.D., Triggs, E.J. and Bourne, D.W.A. 1983 Apple II Program to Simulate the Response - Time Profile of Non-Depolarising Muscle Relaxant, Comput. Biol. Med., 13(3), 171-4 and Ramzan, M.I., Somogyi, A.A., Walker, J.S., Shanks, C.A. and Triggs, E.J. 1981 Clinical Pharmacokinetics of the non-depolarising muscle relaxant, Clin. Pharmacokinetics, 6, p25-60
Last update: Thu 27 Feb 2020 10:01:55 pm
Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available