Multiple IV Bolus - Example Calculations 3

Question 3. A potent drug has been given by multiple IV bolus dose of 50 mg every 6 hours. Assume a one compartment linear model applies to this drug in this concentration range. The Clearance and V for this drug in this patient are 7.8 L/hr and 34.8 L, respectively. Calculate the expected Cpmax and Cpmin values at steady state.


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The Equations:

Cp after multiple doses

Equation 25.1.1 Drug Concentration during a Multiple Dose Regimen (Uniform Regimen)

Cp during at Multiple Dose at Steady State

Equation 25.1.2 Steady State Drug Concentrations after Multiple Dose Regimen (Uniform Regimen)

Fraction Remaining at the End of the Dosing Interval, R

Equation 25.1.3 Fraction Remaining at the End of the Dosing Interval, R

Loading and Maintenance IV Bolus Dose

Equation 25.1.4 Loading and Maintenance IV Dose

Cp after non uniform multiple dose regimen

Equation 25.1.5 Drug Concentration during a Multiple Dose Regimen (Non-Uniform Regimen)


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