2270623184
# Calculation of Drug Concentration

## Uniform Multiple Oral Dose Regimen

A patient is started on a drug at an oral dose of 250 mg every 8 hours. Calculate the drug concentration at a few of time points during the first three dosing interval. Graph these data on semi-log graph paper (The graph is not required for this homework exercise). Specifically calculate the concentration three hours after the first dose, two hours after the second dose and one hour after the third dose.
Assume a one compartment linear model applies to this drug in this concentration range. For this dosage form and patient the bioavailability is 0.81 and the absorption rate constant is 2.82 hr^{-1}.
The half-life and V for this drug in this patient (78 kg) are 4 hr and 0.48 L/kg, respectively.

**The equation:**

**Equation 26.2.1 Drug Concentration, Cp, after Multiple Oral Doses (Uniform Dosing Interval and Dose)**

Last update: Sat 28 Nov 2015 04:52:07 pm

Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available

Copyright © 2002-2020 David Bourne (david@boomer.org)