A previous study with Drug9 resulted in the following data.

t_{1/2} (hr) | CreatinineClearance (ml/min) |

2.86 | 10 |

1.81 | 50 |

1.1 | 120 |

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**Equation 27.1.1 Elimination rate constant calculated from creatinine clearance**

**Equation 27.1.2 Creatinine Clearance calculated from a timed urine collection**

U_{Cr} is the concentration of creatinine in urine in mg/dl, Vu is the volume of urine in ml, S_{Cr} is the serum creatinine concentration in mg/dl and t is the collection time in minutes.

**Equation 27.1.3 Cockcroft and Gault equation for estimating Creatinine Clearance**

Weight in kg and S_{Cr} is the serum creatinine concentration in mg/dl. Note, you should only multiply by 0.85 in the case of female patients. The original authors of this equation used actual body weight in Equation 27.1.3. **More recently it has been recommended that ideal body (IBW) be used in this equation unless the actual body weight (ABW) is less.**
(Murphy, 2001, p4).

IBW (male) (kg) = 50 + 2.3 x (Ht(in) - 60) or IBW (female) (kg) = 45.5 + 2.3 x (Ht(in) - 60) (Murphy, 2001, p4-5)

- Ritschel, W.A. 1980
**Handbook of Basic Pharmacokinetics**, 2nd ed., Drug Intelligence - Murphy, J.E. 2001
**Clinical Pharmacokinetics**, 2nd ed., ASHP, Bethesda, MD - Sarubbi, F.A. and Hull, H.H. 1978. Amikacin serum concentrations: prediction of levels and dosage guidelines,
*Ann. Intern. Med.*,**89**, p 612-618

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