Renal Pharmacokinetics Problem

Questions provided by Teresa Lewis, Pharm.D.

DD is a 30 year-old Native American female with weight 157 lbs and height 71 in, who has a history of hypertension, diabetes and chronic kidney disease. The serum creatinine (Scr) is 1.69 mg/dL. DD is hospitalized with multidrug-resistant Pseudomonas aeruginosa bacteremia. The team wishes to treat this patient with an investigational antibiotic, Drug P. Drug P possesses concentration dependent bactericidal activity. Normal dosing for Drug P is 8 mg/kg/dose intravenously (IV) every 24 hours. Fractional excretion of Drug P is 0.77

1. Using the Cockcroft-Gault formula, calculate the creatinine clearance for DD (round your answer to the nearest whole number).

2. Calculate the dosage adjustment factor for DD's level of renal dysfunction.

3. Estimate an appropriate dosage regimen for DD? (Round the dosing interval to the nearest 12 hours and the dose to the nearest 10 mg)



NOTE: Clicking the button above
will prevent you getting credit for this problem

To get credit for this problem print this page, work the problem and

You will have one chance to submit your answers for this problem [# 2691414460]. You can try the homework problem more than once with different data to improve your grade. Your highest score is recorded. After submitting your answers you can use the browser back arrow to get back here and see how the compuer worked the problem.


Some Equations:

IBW equation (male)
Equation 27.3.1 IBW for Male Patients

IBW equation (female)
Equation 27.3.2 IBW for Female Patients

Creatine Clearance C-G Equation
Equation 27.3.3 Creatinine Clearance (Cockcroft-Gault Equation)

MDRD eGRD Equation
Equation 27.3.4 eGFR (MDRD Eqaution)

Dose Adjustment Factor
Equation 27.3.5 Dose Adjustment Factor

Adjusted Dosing Interval
Equation 27.3.6 Adjusted Dosing Interval

Adjusted Dose
Equation 27.3.7 Adjusted Dose


Last update: Sat 31 Aug 2019 10:13:31 pm
Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available

Copyright © 2002-2020 David Bourne (david@boomer.org)