Aminoglycoside Pharmacokinetics and Pharmacodynamics

Population-Based Dosing

Questions provided by Michele Splinter, Pharm.D.

A 62 year old male is admitted to the hospital with sepsis secondary to a UTI with gram-negative organisms seen on gram stain of urine. His admission weight is 176 lb, and he is 6' 3" tall. He has chronic renal insufficiency which is stable with an admission serum creatinine of 1.169 mg/dl. The physician decides to start gentamicin and wants to obtain peak serum concentrations of 6 mg/L and trough serum concentrations of 1 mg/L or less. Assume a volume of distribution of 0.25 L/kg based on body weight. Based on your knowledge of estimation of creatinine clearance and gentamicin elimination rate constant [kel (hr^-1) = 0.01 + 0.0024 (CL_cr in mL/min)], calculate kel, t_1/2, Vd, CL. What loading dose (rounded down to the nearest 10 mg), maintenance dose (round down to the nearest 10 mg) and dosing interval (up to the nearest 12 hr) would you recommend? Infusion duration should be fixed at 1 hour.

NOTE: Clicking the button above
will prevent you getting credit for this problem

To get credit for this problem print this page, work the problem and

You will have one chance to submit your answers for this problem [# 1150433008]. You can try the homework problem more than once with different data to improve your grade. Your highest score is recorded. After submitting your answers you can use the browser back arrow to get back here and see how the compuer worked the problem.

Some Equations:

Equation 27.4.1 IBW for Male Patients

Equation 27.4.2 IBW for Female Patients

Creatine Clearance C-G Equation
Equation 27.4.3 Creatinine Clearance (Cockcroft-Gault Equation)

Equation 27.4.4 Dosing Interval, τ

Equation 27.4.5 Maintenance Dose

Equation 27.4.6 Loading Dose

Last update: Sun 1 Sep 2024 09:15:58 pm

Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available