|Serum creatinine (Scr)||1.2||mg/dL|
|Blood urea nitrogen (BUN)||15||mg/dL|
|White blood cells (WBC)||12.7||K cells/mm3|
|Maximum temperature (Tmax)||38.0||°C|
|Date||Time||Dose||Infusion Duration||Serum Vancomycin Concentration|
|9/24||1000||1500 mg||1.5 hour|
|9/24||1205||0 - Post dose peak|
|9/24||2130||0 - Pre dose trough|
With these data calculate kel, t1/2, Vd, CL, Cpmax and Cpmin.
B. Calculate a reasonable dosing interval (nearest 12 hr) and maintenance dose (nearest 250 mg), infusion duration (to the nearest 15 minutes) to achieve a peak serum concentration (Cpmaxss) of 55 mg/L and a trough concentration (Cpminss) of 10 mg/L. Calculate projected Cpmaxss and Cpminss on the new regimen.
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Equation 27.5.2 IBW for Female Patients
Equation 27.5.3 Creatinine Clearance (Cockcroft-Gault Equation)
Equation 27.5.5 Dosing Interval, τ
Equation 27.5.6 Maintenance Dose