|Age: 66 yr||Gender: male||Weight: 51.4 kg||ht: 73 in|
|Scr: 1.82 mg/dL||Organism MIC 0.5 mg/L|
A. Using the following population based estimates for vancomycin:
Vancomycin kel (hr-1) = 0.0044 + 0.00083 * (CLcr in mL/min)
Vancomycin Vd = 0.7 L/Kg * (Total Body Weight in Kg)
Calculate kel, t1/2, Vd, CL.
B. Use the calculated patient parameters to determine a dosing interval (to the nearest 12 hr), infusion duration (to the nearest 15 minutes) and maintenance dose (to the nearest 250 mg) to produce a Cpmaxss of 60 mg/L and a Cpminss of 20 mg/L. Calculate the projected Cpmaxss and Cpminss on the new regimen.
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Equation 27.5.2 IBW for Female Patients
Equation 27.5.3 Creatinine Clearance (Cockcroft-Gault Equation)
Equation 27.5.5 Dosing Interval, τ
Equation 27.5.6 Maintenance Dose
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