Vancomycin Pharmacokinetics and Pharmacodynamics

Questions provided by Michele Splinter, Pharm.D.

There are two question types on this page.
You might try answering both types even if you got full credit for one type.

A. 46 y/o, 86.8 kg, 72 in. male patient is diagnosed with osteomyelitis following projectile penetration of his left tibia when mowing the yard. The organism has been identified as methicillin resistant Staphylococcus aureus. Vancomycin therapy was begun on 9/24 at 10AM with dosing of 1500 mg IV once over 1.5 hour. The vancomycin MIC is 1.8 mg/L. Serum concentrations were obtained after the patient's first dose. The patient's laboratory values and vancomycin dosing history are:

**Laboratory Values**
Date	11/30	Unit
Serum creatinine (Scr)	1.2	mg/dL
Blood urea nitrogen (BUN)	15	mg/dL
White blood cells (WBC)	12.7	K cells/mm³
Maximum temperature (Tmax)	38.0	°C

Vancomycin Dosing History
Date Time Dose Infusion Duration Serum Vancomycin Concentration

9/24 1000 1500 mg 1.5 hour

9/24 1240 26.3 - Post dose peak

9/24 2125 5.59 - Pre dose trough

**Vancomycin Dosing History**
Date	Time	Dose	Infusion Duration	Serum Vancomycin Concentration
9/24	1000	1500 mg	1.5 hour
9/24	1240			26.3 - Post dose peak
9/24	2125			5.59 - Pre dose trough

With these data calculate kel, t_1/2, Vd, CL, Cp_max and Cp_min.

B. Calculate a reasonable dosing interval (nearest 12 hr) and maintenance dose (nearest 250 mg), infusion duration (to the nearest 15 minutes) to achieve a peak serum concentration (Cp_max^ss) of 45 mg/L and a trough concentration (Cp_min^ss) of 10 mg/L. Calculate projected Cp_max^ss and Cp_min^ss on the new regimen.

NOTE: Clicking the button above
will prevent you getting credit for this problem

To get credit for this problem print this page, work the problem and

You will have one chance to submit your answers for this problem [# 1150519437]. You can try the homework problem more than once with different data to improve your grade. Your highest score is recorded. After submitting your answers you can use the browser back arrow to get back here and see how the compuer worked the problem.

Some Equations:

Equation 27.5.1 IBW for Male Patients

Equation 27.5.2 IBW for Female Patients

Creatine Clearance C-G Equation
Equation 27.5.3 Creatinine Clearance (Cockcroft-Gault Equation)

Equation 27.5.5 Dosing Interval, τ

Equation 27.5.6 Maintenance Dose

Last update: Sat 27 Jul 2024 08:10:12 pm

Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available

Vancomycin Pharmacokinetics and Pharmacodynamics

Questions provided by Michele Splinter, Pharm.D.

There are two question types on this page.You might try answering both types even if you got full credit for one type.

There are two question types on this page.
You might try answering both types even if you got full credit for one type.