Patient data is as follows: Ht = 75 in. Wt = 105 kg. Scr = 1.06 mg/dL.
The following represent the dosing history:
Based on the following doses and serum concentrations, calculate the following: ke, t1/2, Vd, CL, infusion dose (round down to the nearest 10 mg) over 1 hr, dosing interval (round up to the nearest 12 hr), projected Cpmaxss and Cpminss with target Cpmaxss = 9 mg/L and Cpminss = less than 1 mg/L and time from the last sample to starting the next dose (to the nearest hour).
| Date | Time | Dosage | Infusion Duration | Serum Concentration |
|---|---|---|---|---|
| 09/17/15 | 0900 | 180 mg | 1 hr | |
| 09/17/15 | 2100 | 180 mg | 1 hr | |
| 09/18/15 | 0900 | 180 mg | 1 hr | |
| 09/18/15 | 2100 | 180 mg | 1 hr | |
| 09/19/15 | 0900 | 180 mg | 1 hr | |
| 09/19/15 | 2059 | 3.98 mg/L | ||
| 09/19/15 | 2100 | 180 mg | 1 hr | |
| 09/19/15 | 2255 | 11.29 mg/L |
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Equation 27.4.2 IBW for Female Patients
Equation 27.4.3 Creatinine Clearance (Cockcroft-Gault Equation)
Equation 27.4.4 Apparent Volume of Distribution, Vd
Equation 27.4.5 Dosing Interval, τ
Equation 27.4.6 Loading Dose
Equation 27.4.7 Maintenance Dose
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