# Two compartment IV Bolus - Example Calculations

# Micro to Macro Constants

Question 1.
A drug follows first order (i.e. linear) two compartment pharmacokinetics. After looking in the literature we find a number of parameter values for this drug. These numbers represent the micro constants for this drug. In order that we can calculate the drug concentration after a single IV bolus dose these parameters need to be converted into values for the macro constants.
The kel and V1 for this drug in this patient are 0.202 hr^{-1} and 24.3 L, respectively.
The k12 and k21 values this drug are 2.83 and 1.56 hr^{-1}, respectively. What is the plasma concentration of this drug 3 hours after a 50 mg, IV Bolus dose. In order to complete this calculation first calculate the appropriate A, B, α and β values.

NOTE: Clicking the button above

will prevent you getting credit for this problem

Print this page if you want, work the problems and

You will have one chance to submit your answers for this problem [# 2691250577]. You can try the homework problem more than once with different data to improve your grade. Your highest score is recorded. After submitting your answers you can use the browser back arrow to get back here and see how the compuer worked the problem.

**Some Equations:**

**Equation 30.1.1 Cp versus Time after an IV Bolus - Two compartment model**

**Equation 30.1.2 α plus β**

**Equation 30.1.3 α times β**

**Equation 30.1.4 α or β**

**Equation 30.1.5 A value**

**Equation 30.1.6 B value**

Last update: Sat 27 Apr 2019 09:54:25 pm

Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available

Copyright © 2002-2020 David Bourne (david@boomer.org)