Two compartment IV Bolus - Example Calculations

Macro to Micro Constants - Volumes of Distribution

Question 1. A drug follows first order (i.e. linear) two compartment pharmacokinetics. A dose of 50 mg was given by IV bolus and a number of blood samples were collected and analyzed for drug plasma concentration. After a successful analysis using the method of residuals values of A, B, α and β were determined to be 4.43 mg/L, 5.99 mg/L, 2.69 hr-1 and 0.1 hr-1, respectively.

Calculate V1, Varea, Vss, kel, k12 and k21 for this drug.


NOTE: Clicking the button above
will prevent you getting credit for this problem

Print this page if you want, work the problems and

You will have one chance to submit your answers for this problem [# 460914114]. You can try the homework problem more than once with different data to improve your grade. Your highest score is recorded. After submitting your answers you can use the browser back arrow to get back here and see how the compuer worked the problem.


Some Equations:

k21 =

Equation 30.1.7 Equation for k21

kel =

Equation 30.1.8 Equation for kel

k12 =

Equation 30.1.9 Equation for k12

V1 =

Equation 30.1.10 Equation for V1

Varea =

Equation 30.1.11 Equation for Varea

Vss =

Equation 30.1.12 Equation for Vss


Last update: Sat 27 Jul 2024 08:10:12 pm
Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available

Copyright © 2002-2024 David Bourne (david@boomer.org)