Two compartment IV Bolus - Example Calculations

Macro to Micro Constants - Volumes of Distribution

Question 1. A drug follows first order (i.e. linear) two compartment pharmacokinetics. A dose of 10 mg was given by IV bolus and a number of blood samples were collected and analyzed for drug plasma concentration. After a successful analysis using the method of residuals values of A, B, α and β were determined to be 4.68 mg/L, 5.35 mg/L, 3.69 hr-1 and 0.1 hr-1, respectively.

Calculate V1, Varea, Vss, kel, k12 and k21 for this drug.

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Some Equations:

k21 =

Equation 30.1.7 Equation for k21

kel =

Equation 30.1.8 Equation for kel

k12 =

Equation 30.1.9 Equation for k12

V1 =

Equation 30.1.10 Equation for V1

Varea =

Equation 30.1.11 Equation for Varea

Vss =

Equation 30.1.12 Equation for Vss

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