Time (hr) | Cp (mg/L) | ||
0.25 | 0.877 | ||
0.5 | 0.695 | ||
0.75 | 0.592 | ||
1 | 0.528 | ||
1.25 | 0.484 | ||
1.5 | 0.45 | ||
2 | 0.398 | ||
4 | 0.255 | ||
6 | 0.164 | ||
9 | 0.085 | ||
12 | 0.044 |
Equation 30.31 Drug Concentration, Cp, after IV bolus dose - Two compartment
The table above provides a set of data for you to analyze. Using these data you should be able to estimate the slow rate constant, the β rate constant. You can then calculate the residual as the difference between early observed drug concentration values and the extrapolated Cp_{late} values. The plot of this residual on semi-log graph paper then provides an estimate of the faster rate constant, the α rate constant.
Estimate A, B, α and β. Does the ratio of α to β satisfy the requirement of the method of residuals?
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