|Time (hr)||Cp (mg/L)|
Equation 30.31 Drug Concentration, Cp, after IV bolus dose - Two compartment
The table above provides a set of data for you to analyze. Using these data you should be able to estimate the slow rate constant, the β rate constant. You can then calculate the residual as the difference between early observed drug concentration values and the extrapolated Cplate values. The plot of this residual on semi-log graph paper then provides an estimate of the faster rate constant, the α rate constant.
Estimate A, B, α and β. Does the ratio of α to β satisfy the requirement of the method of residuals?
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