Time (hr) | Cp (mg/L) | ||
0.25 | 0.53 | ||
0.5 | 0.49 | ||
0.75 | 0.46 | ||
1 | 0.44 | ||
1.25 | 0.43 | ||
1.5 | 0.42 | ||
2 | 0.4 | ||
4 | 0.34 | ||
6 | 0.29 | ||
9 | 0.23 | ||
12 | 0.18 |
Equation 30.31 Drug Concentration, Cp, after IV bolus dose - Two compartment
The table above provides a set of data for you to analyze. Using these data you should be able to estimate the slow rate constant, the β rate constant. You can then calculate the residual as the difference between early observed drug concentration values and the extrapolated Cplate values. The plot of this residual on semi-log graph paper then provides an estimate of the faster rate constant, the α rate constant.
Estimate A, B, α and β. Does the ratio of α to β satisfy the requirement of the method of residuals?
You will have one chance to submit your answers for this problem [# 460751175]. You can try the homework problem more than once with different data to improve your grade. Your highest score is recorded. After submitting your answers you can use the browser back arrow to get back here and see how the compuer worked the problem.
Material on this website should be used for Educational or Self-Study Purposes Only
iBook and pdf versions of this material and other PK material is available