Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 8.77 | 0 | 0 | 0 | 0 | 0 |

0.25 | 5.99 | 1.85 | 1.85 | 1.5 | 0.187 | 0.187 |

0.5 | 4.32 | 1.29 | 3.13 | 2.16 | 0.457 | 0.644 |

0.75 | 3.32 | 0.955 | 4.09 | 2.49 | 0.581 | 1.23 |

1 | 2.71 | A | C | 2.71 | 0.65 | 1.88 |

1.25 | 2.34 | B | 5.47 | 2.93 | 0.704 | 2.58 |

1.5 | 2.11 | 0.556 | 6.03 | 3.17 | D | F |

2 | 1.87 | 0.995 | 7.03 | 3.74 | E | 5.07 |

4 | 1.59 | 3.46 | 10.5 | 6.36 | 10.1 | 15.2 |

6 | 1.43 | 3.02 | 13.5 | 8.58 | 14.9 | 30.1 |

9 | 1.23 | 3.99 | 17.5 | 11.1 | 29.5 | 59.6 |

12 | 1.05 | 3.42 | 20.9 | 12.6 | 35.5 | 95.1 |

24 | 0.57 | 9.72 | 30.6 | 13.7 | 158 | 253 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Sat 28 Nov 2015 09:52:07 am