Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 6.03 | 0 | 0 | 0 | 0 | 0 |

0.25 | 4.23 | 1.28 | 1.28 | 1.06 | 0.132 | 0.132 |

0.5 | 3.46 | 0.961 | 2.24 | 1.73 | 0.348 | 0.481 |

0.75 | 3.09 | 0.819 | 3.06 | 2.32 | 0.506 | 0.987 |

1 | 2.88 | A | C | 2.88 | 0.65 | 1.64 |

1.25 | 2.74 | B | 4.51 | 3.43 | 0.788 | 2.42 |

1.5 | 2.62 | 0.67 | 5.18 | 3.93 | D | F |

2 | 2.43 | 1.26 | 6.44 | 4.86 | E | 5.54 |

4 | 1.8 | 4.23 | 10.7 | 7.2 | 12.1 | 17.6 |

6 | 1.34 | 3.14 | 13.8 | 8.04 | 15.2 | 32.8 |

9 | 0.854 | 3.29 | 17.1 | 7.69 | 23.6 | 56.4 |

12 | 0.546 | 2.1 | 19.2 | 6.55 | 21.4 | 77.8 |

24 | 0.0913 | 3.82 | 23 | 2.19 | 52.5 | 130 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Sat 28 Nov 2015 09:52:07 am