Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 9.01 | 0 | 0 | 0 | 0 | 0 |

0.25 | 6.6 | 1.95 | 1.95 | 1.65 | 0.206 | 0.206 |

0.5 | 5.39 | 1.5 | 3.45 | 2.7 | 0.543 | 0.749 |

0.75 | 4.74 | 1.27 | 4.72 | 3.56 | 0.781 | 1.53 |

1 | 4.37 | A | C | 4.37 | 0.991 | 2.52 |

1.25 | 4.13 | B | 6.92 | 5.16 | 1.19 | 3.71 |

1.5 | 3.95 | 1.01 | 7.93 | 5.93 | D | F |

2 | 3.67 | 1.91 | 9.83 | 7.34 | E | 8.42 |

4 | 2.85 | 6.52 | 16.4 | 11.4 | 18.7 | 27.2 |

6 | 2.22 | 5.07 | 21.4 | 13.3 | 24.7 | 51.9 |

9 | 1.52 | 5.61 | 27 | 13.7 | 40.5 | 92.4 |

12 | 1.05 | 3.86 | 30.9 | 12.6 | 39.4 | 132 |

24 | 0.233 | 7.7 | 38.6 | 5.59 | 109 | 241 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Sat 28 Nov 2015 09:52:07 am