Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 1.09 | 0 | 0 | 0 | 0 | 0 |

0.25 | 0.722 | 0.227 | 0.227 | 0.181 | 0.0226 | 0.0226 |

0.5 | 0.573 | 0.162 | 0.388 | 0.287 | 0.0584 | 0.0809 |

0.75 | 0.511 | 0.136 | 0.524 | 0.383 | 0.0837 | 0.165 |

1 | 0.483 | A | C | 0.483 | 0.108 | 0.273 |

1.25 | 0.469 | B | 0.767 | 0.586 | 0.134 | 0.407 |

1.5 | 0.46 | 0.116 | 0.883 | 0.69 | D | F |

2 | 0.448 | 0.227 | 1.11 | 0.896 | E | 0.963 |

4 | 0.408 | 0.856 | 1.97 | 1.63 | 2.53 | 3.49 |

6 | 0.373 | 0.781 | 2.75 | 2.24 | 3.87 | 7.36 |

9 | 0.325 | 1.05 | 3.79 | 2.93 | 7.74 | 15.1 |

12 | 0.283 | 0.912 | 4.71 | 3.4 | 9.48 | 24.6 |

24 | 0.164 | 2.68 | 7.39 | 3.94 | 44 | 68.6 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Sat 28 Nov 2015 09:52:07 am