Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 6.49 | 0 | 0 | 0 | 0 | 0 |

0.25 | 4.43 | 1.37 | 1.37 | 1.11 | 0.138 | 0.138 |

0.5 | 3.51 | 0.993 | 2.36 | 1.76 | 0.358 | 0.496 |

0.75 | 3.07 | 0.823 | 3.18 | 2.3 | 0.507 | 1 |

1 | 2.83 | A | C | 2.83 | 0.642 | 1.65 |

1.25 | 2.69 | B | 4.61 | 3.36 | 0.774 | 2.42 |

1.5 | 2.59 | 0.66 | 5.27 | 3.89 | D | F |

2 | 2.43 | 1.26 | 6.52 | 4.86 | E | 5.51 |

4 | 1.93 | 4.36 | 10.9 | 7.72 | 12.6 | 18.1 |

6 | 1.54 | 3.47 | 14.4 | 9.24 | 17 | 35.1 |

9 | 1.1 | 3.96 | 18.3 | 9.9 | 28.7 | 63.8 |

12 | 0.781 | 2.82 | 21.1 | 9.37 | 28.9 | 92.7 |

24 | 0.2 | 5.89 | 27 | 4.8 | 85 | 178 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Sat 28 Nov 2015 09:52:07 am