Non compartment Analysis IV Administration

A drug follows first order (i.e. linear) pharmacokinetics. A 150 mg dose was given by rapid IV administration to a patient and a number of plasma drug concentration were determined. The results are shown in the table below. A non compartmental analysis was completed and AUC and AUMC values calculated. As you can see some of these values are missing from the table. Complete the table and estimate MRT, CL, and Vss from these data.

Time
hr
Cp
mg/L
ΔAUC
mg.hr/L
AUC
mg.hr/L
Cp • t
mg.hr/L
ΔAUMC
mg.hr2/L
AUMC
mg.hr2/L
01.4800000
0.251.090.3210.3210.2730.03410.0341
0.50.8960.2480.570.4480.09010.124
0.750.7850.210.780.5890.130.254
10.715AC0.7150.1630.417
1.250.663B1.140.8290.1930.61
1.50.6210.1611.30.932DF
20.5520.2931.591.1E1.34
40.3520.9042.51.412.513.85
60.2250.5773.071.352.766.61
90.1150.513.581.043.5810.2
120.05890.2613.840.7072.6112.8
240.004030.3784.220.09674.8217.6
Infinity0GH0IJ

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