Timehr |
Cpmg/L |
ΔAUCmg.hr/L |
AUCmg.hr/L |
Cp • tmg.hr/L |
ΔAUMCmg.hr ^{2}/L |
AUMCmg.hr ^{2}/L |

0 | 2.29 | 0 | 0 | 0 | 0 | 0 |

0.25 | 1.54 | 0.479 | 0.479 | 0.385 | 0.0481 | 0.0481 |

0.5 | 1.16 | 0.338 | 0.816 | 0.58 | 0.121 | 0.169 |

0.75 | 0.966 | 0.266 | 1.08 | 0.725 | 0.163 | 0.332 |

1 | 0.857 | A | C | 0.857 | 0.198 | 0.53 |

1.25 | 0.793 | B | 1.52 | 0.991 | 0.231 | 0.761 |

1.5 | 0.749 | 0.193 | 1.71 | 1.12 | D | F |

2 | 0.69 | 0.36 | 2.07 | 1.38 | E | 1.65 |

4 | 0.532 | 1.22 | 3.29 | 2.13 | 3.51 | 5.16 |

6 | 0.413 | 0.945 | 4.24 | 2.48 | 4.61 | 9.76 |

9 | 0.283 | 1.04 | 5.28 | 2.55 | 7.54 | 17.3 |

12 | 0.193 | 0.714 | 5.99 | 2.32 | 7.29 | 24.6 |

24 | 0.0422 | 1.41 | 7.4 | 1.01 | 20 | 44.6 |

Infinity | 0 | G | H | 0 | I | J |

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**Equation 30.4.1 AUC for the segment from i-1 to i**

**Equation 30.4.2 AUC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of Cp versus time on semi-log graph paper.

**Equation 30.4.3 AUMC for the last segment from t _{last} to infinity**

where k' is the slowest rate constant. k' can be calculated from the terminal slope of **Cp versus time** on semi-log graph paper.

**Equation 30.4.4 Mean Resident Time (MRT)**

**Equation 30.4.5 Clearance (CL)**

**Equation 30.4.6 Steady State Apparent Volume of Distribution, V _{ss}**

Last update: Sat 28 Nov 2015 09:52:07 am