Slide 12 Slide showing a model with the various routes of administration. Later we will discuss different routes of administration and see how these effect the kinetics of drug disposition. For example absorption through the lining of the mouth, buccal absorption, often results in rapid absorption without the drug passing through the liver where it can be broken down. However, only low dose drugs can be accommodated by this ROA. Orally absorbed drugs are absorbed in the stomach or intestines and enter the portal blood supply and go to the liver before getting into the central blood supply. This can result in extensive metabolism of the drug before it can take any action. For this reason some drugs are very inefficient when given orally.

Copyright 2001 David W.A. Bourne