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Excretion Unchanged - No Metabolism

First we'll consider the case in which the drug is excreted totally as the unchanged drug into urine.

Scheme or diagram

The scheme is then:-

Diagram V-1, Scheme for drug excreted into urine, one compartment

Differential equation

Since the rate of elimination from plasma is the same as the rate of appearance of drug into urine.

Equation V-1. Differential Equation for Cumulative amount Excreted

Since according to this model, the drug is either in the body or has been eliminated into urine.

Dose = Amount in body + Amount excreted = V * Cp + U


This page was last modified: 12 February 2001

Copyright 2001 David W.A. Bourne


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