Diagram V-2. Schematic for drug eliminated by excretion and metabolism
ke is the excretion rate constant and km is the metabolism rate constant. Here we have two parallel pathways for elimination (with others as a shadow). We can write the differential equations for the three components shown in this diagram. There could be more pathways. It may be appropriate to specify excretion by exhalation, in sweat, or as is commonly the case, more than one metabolite.
Copyright 2001 David W.A. Bourne