IX Calculation of Bioavailability Parameters


=> To appropriately use the method of Residuals and the method of Wagner and Nelson to calculate ka

=> To calculate F using plasma or urine data

On most occasions you will be able to get the parameter values from tables and references. However, you should also know how to get these values from the data. The two parameters we will concentrate on are ka and F. These values can be used to compare dosage forms or brands. In the previous Chapter we saw the effect changing ka or F has on the plasma concentration time curve.

This page was last modified: 12 February 2001

Copyright 2001 David W.A. Bourne