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Finger Print Method - Example 3

The differential equation for amount of drug in body according to the two compartment model after an IV bolus (Dose) can be written as:

Laplace transform of amount in body IV Bolus Two Compartment

Equation 7.6.1 Laplace Transform of Amount in the Body after an IV Bolus - Two Compartment model

Note that the denominator has a power of 2 in s and no repeating terms. The numerator has a power of 1 in s. Therefore the fingerprint method can be applied.

Setting the denominator to zero:

(s + α) * (s + β) = 0

gives the two roots -α and -β.

The finger print method can then be applied as illustrated in the QuickTime® movie below.

Figure 7.6.1 Movie illustrating the Finger Print Method - 1

The solution

X = A' x e-α x t + B' x e-β x t

Equation 7.6.2 Integrated Equation for Amount in the Body after an IV Bolus - Two Compartment


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