Laplace Transform Examples

One Compartment Models

Administration by IV Bolus - Rapid IV Injection

Assuming that the total dose is placed in the blood/body component at time zero
  1. Amount of Drug in the Body - in context
  2. Amount of Drug in Urine - in context
  3. Amount of Metabolite in the Body
  4. Amount of Metabolite in Urine - in context

Administration by Oral Administration

Assuming that the total dose is placed in the GI Tract component at time zero
  1. Amount of Drug in the GI Tract
  2. Amount of Drug in the Body
  3. Amount of Drug in Urine
  4. Amount of Metabolite in the Body
With absorption and dissolution
  1. Amount of Drug in the Body
With absorption from the stomach and the intestine
  1. Amount of Drug in the Body

Administration by IV Infusion

Assuming no drug is in the blood/body component at time zero
  1. Amount of Drug in the Body
  2. Amount of Drug in Urine

Consider other models using the 'Convolution Machine'


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