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redrawn from Juncher and Raaschou, 1957
Fig 3.16.1 Slide showing plasma penicillin concentration versus time curve after oral administration of various salts. The rate at which a drug dissolves is dependent on the solubility of the drug. A common occurrence is that different salts will have quite different solubility characteristics, and again somewhat different to the free acid (or base) form. In the case of penicillin V it appears that only drug which is dissolved quickly can be absorbed.
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