Chapter 3 Biopharmaceutics and Pharmacokinetic Introduction

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Drug Effect and Absorption

redrawn from Wagner, 1961

Fig 3.17.1 Slide showing blood sugar levels after tolbutamide acid and salt. Rapid dissolution and absorption is not always the objective. Sometimes a slower release is required. In the case of tolbutamide, used to lower blood sugar concentrations, a more sustained release is better causing a more gradual reduction in blood sugar.

References

Wagner, J.G. 1961 Biopharmaceutics: absorption aspects, J. Pharm. Sci., 50, 359

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