Chapter 3 Biopharmaceutics and Pharmacokinetic Introduction

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Elimination and Multiple Dose

Fig 3.22.1 Slide showing multiple dose curves with slow, medium, and fast excretion. Alteration of drug elimination is particularly important when drugs are given repeatedly. If it is assumed that the drug is eliminated normally when in fact it is slowly eliminated, drug accumulation may occur with toxic concentrations reached. Alternately faster elimination than expected may cause sub therapeutic concentrations to be reached.

References

Dittert, L.W. 1974 Pharmacokinetic Considerations in Clinical Drug Trials, Drug Intelligence and Clin. Pharmacy, 8, 222-30

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