Chapter 3

Biopharmaceutics and Pharmacokinetic Introduction

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Dosing Kanamycin

Fig 3.23.1 Slide showing a clinical example with kanamycin, showing theoretical curve after multiple dose and a better curve after dose adjustment. Kanamycin is a useful drug but it can cause some serious side effects. By controlling the blood concentration of this drug it is possible to use it effectively. In the case of patients with impaired renal, or kidney, function it is possible to determine the kidney function ahead of time and adjust the kanamycin dosing schedule accordingly.

• Dittert, L.W. 1974 Pharmacokinetic Considerations in Clinical Drug Trials, Drug Intelligence and Clin. Pharmacy, 8, 222-30

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