Chapter 3 Biopharmaceutics and Pharmacokinetic Introduction

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Renal Disease and Drug Elimination

Fig 3.24.1 Slide showing relationship between kanamycin half-life and serum creatinine level. As kidney function is reduced the serum creatinine level increases and the also the kanamycin takes longer to be eliminated from the body.

References

Cutler, R.E. and Orme, B.M. 1969 Correlation of Serum Creatinine Concentration and Kanamycin Half-Life, J. Amer. Med. Assoc., 209 (4), 539-42

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