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Make Predictions

Once we have a model and parameter values we can use this information to make predictions. For example we can determine the dose required to achieve a certain drug concentration.

Information for dose calculation

Figure 6.4.1 Dose required to achieve a certain plasma concentration

Using these data we can calculate (or predict) the drug concentrations at various time up to and including the six hours requested.

Plot of cp versus time out to six hours

Figure 6.4.2 Plasma concentration versus time after a 65 mg IV bolus dose

We can also predict drug concentrations after a specified drug dosage regimen.

Cp after multiple IV bolus doses

Figure 6.4.3 Concentrations after multiple IV Bolus doses

With this information we can predict drug plasma concentrations after multiple 100 mg IV bolus doses every 12 hours.

Plot of Cp versus time after multiple IV bolus doses

Figure 6.4.4 Linear plot of drug concentration versus time after multiple IV Bolus doses

With more extensive models even more involved predictions or calculations can be performed.


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