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Figure 8.3.1 Diagram representing a one compartment model
The next step is to convert the parts in the model to parameters from the Boomer parameter toolbox. This could be done by notation on the diagram above or by preparing a table of parameter types. Currently the available parameter types within Boomer include:
Figure 8.3.2 Parameter types available with Boomer (Dec 2002)
The model in Figure 8.3.1 has one first order rate constant (a type 2 parameter), a dose (type 1), and an apparent volume of distribution (type 18). These can represented in tabular form before starting the program.
Table 8.3.1 Parameter types and values for the model in Figure 8.3.1
Now it is time to start the program. Boomer is a menu driven program. That is, once started the program will present the user with a set sequence of menu choices. Initially the user will select input and output options and 'Normal Fitting' for nonlinear regression analysis. The model is described to the program through a series of questions and prompts. Fitting and optimization algorithms are selected. Finally the data and weighting schemes are entered. The program will hopefully finish satisfactorily and produce useful output.
Refer to the Boomer manual for more detail. Boomer (Reference https://www.boomer.org/)
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