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Figure 8.5.1 Selection of the model
The first selection is the general category of compiled models and the second the specific model, IV bolus first order elimination.
Data is entered in a spreadsheet window, in this case in columns A and B for time and Cp values respectively.
Figure 8.5.2 Data entry window
The next step is to link the data in the spreadsheet and apply a weight.
Figure 8.5.3 Link data to the specified model
The next step is to enter the initial estimates for the parameters and to provide dose information.
Figure 8.5.4 Entry of parameter estimates and dose information
Refer to the WinNonlin manual for more detail. WinNonlin (Reference https://www.certara.com/software/pkpd-modeling-and-simulation/phoenix-winnonlin/)
Screen shots are from an older versions of WinNonlin.
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