Chapter 7 Routes of Drug Administration

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Inhalation

May be used for a local effect, e.g. bronchodilators.

Can be used for systemic effect, e.g. general anesthesia.

Rapid absorption by-passing the liver.

Absorption of gases is relatively efficient, however solids and liquids are excluded if larger than 20 micron and even then only 10 % of the dose may be absorbed. Cromolyn is taken as a powder with 50 % of the particles within the range of 2 to 6 micron. Larger than 20 micron and the particles impact in the mouth and throat. Smaller than 0.5 micron and they aren't retained. Some portion of the dose may be swallowed.

Figure 7.8.1 Typical Plot of Cp versus Time after Inhalation Administration

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Pharmacy Math Part One
A selection of Pharmacy Math Problems