Chapter 13 Formulation Factors

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Suspension Dosage Forms

A well formulated suspension is second only to a solution in terms of superior bioavailability. Absorption may well be dissolution limited, however a suspension of a finely divided powder will maximize the potential for rapid dissolution. A good correlation can be seen for particle size and absorption rate. With very fine particle sizes the dispersibility of the powder becomes important. The addition of a surface active agent will improve dispersion of a suspension and may improve the absorption of very fine particle size suspensions otherwise caking may be a problem. As a suspension ages there is potential for increased particle size with an accompanying decrease in dissolution rate. Smaller particles have higher solubility and will tend to disappear with the drug coming out of solution on larger particles.

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