Chapter 13 Formulation Factors

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Capsule Dosage Forms

In theory a capsule dosage form should be quite efficient. The hard gelatin shell should disrupt rapidly and allow the contents to be mixed with the G-I tract contents. The capsule contents should not be subjected to high compression forces which would tend to reduce the effective surface area, thus a capsule should perform better than a tablet. This is not always the case. If a drug is hydrophobic a dispersing agent should be added to the capsule formulation. These diluents will work to disperse the powder, minimize aggregation and maximize the surface area of the powder. Tightly packed capsules may have reduced dissolution and bioavailability.

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