Pharmacokinetics
This Course in ePub format
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Boomer Batch File
4 wls,bayes,sim,irwls,sim+error,grid Note 1
1 Screen, diskfile
f2121kelV
1 Parameter type
Dose
100.0 Parameter value
0 Fixed,adjust,depend1,depend2
1 To
0 F-dependence ?
0 happy or not
2 Parameter type
kel
0.2000 Parameter value
1 Fixed,adjust,depend1,depend2 Note 2
0.19990
0.20001
2
0.01
0 To
1 From
0 happy or not
18 Parameter type
V
15.00 Parameter value
1 Fixed,adjust,depend1,depend2 Note 2
14.999
15.001
2
0.01
1 To
Cp
1 From
0 happy or not
-1 Parameter type
2 Integration method
0.000 Relative error
0.000 Absolute error
Simulation kel varying
1 Data from disk or keyboard
0.000 X value
0.000 Y value
1.000 X value
0.000 Y value
2.000 X value
0.000 Y value
3.000 X value
0.000 Y value
4.000 X value
0.000 Y value
5.000 X value
0.000 Y value
6.000 X value
0.000 Y value
7.000 X value
0.000 Y value
8.000 X value
0.000 Y value
9.000 X value
0.000 Y value
10.00 X value
0.000 Y value
-1.000 X value
0 Accept, correct, delete, insert, of
0 Continue or save data
0 Error type for line
0 Weight type Note 3
0 AUC line number
10 Continue,save,plot,supplemental,sen Note 4
-1 wls,bayes,sim,irwls,sim+error,grid
Note 1 Select 'Simulation with random error or sensitivity analysis'
Note 2 Set parameters to be adjustable. Enter 'known' parameter values and set close upper and lower limits
Note 3 Select equal weight. Other weighting is possible but interpretation is curious
Note 4
Select option 10 for graphs and sensitivity
The output of this run is shown in Figure 21.4.2.
** FINAL OUTPUT FROM Boomer (v3.4.7) ** 16 February 2021 --- 11:36:35 am Title: Simulation kel varying Input: From f2121kelv.BAT Output: To f2121kelV.OUT Data for Cp came from keyboard (or ?.BAT) Fitting algorithm: Simulation with Error Note 1 Weighting for Cp by Equal weight Numerical integration method: 2) Fehlberg RKF45 with 1 de(s) With relative error 0.1000E-03 With absolute error 0.1000E-03 This simulation took 0.3800 seconds # Name Value Low Original High 1) kel 0.20001 0.200 0.20 0.20 Note 2 2) V 15.000 15.0 15. 15. Model and Parameter Definition # Name Value Type From To Dep Start Stop 1) Dose = 100.0 1 0 1 0 0 0 2) kel = 0.2000 2 1 0 0 0 0 3) V = 15.00 18 1 1 0 0 0 Data for Cp :- DATA # Time Observed Calculated (Weight) Weighted residual 1 0.000 0.00000 6.66644 1.00000 0.00000 2 1.000 0.00000 5.45798 1.00000 0.00000 3 2.000 0.00000 4.46859 1.00000 0.00000 4 3.000 0.00000 3.65854 1.00000 0.00000 5 4.000 0.00000 2.99534 1.00000 0.00000 6 5.000 0.00000 2.45236 1.00000 0.00000 7 6.000 0.00000 2.00781 1.00000 0.00000 8 7.000 0.00000 1.64384 1.00000 0.00000 9 8.000 0.00000 1.34586 1.00000 0.00000 10 9.000 0.00000 1.10189 1.00000 0.00000 11 10.00 0.00000 0.902141 1.00000 0.00000 Plots of observed (*) and calculated values (+) versus time for Cp. Superimposed points (X) 6.666 Linear 6.666 Semi-log |+ |+ | | | | | | | | + | | | + | | | + | | | | | + | + | | | | | | + | + | | | | | + | + | | | | + | + | | | + | | | + | + | | + | | | + | + + | | | | | + | | |* * * * * * * * * * * | + |_____________________________________ |*__*___*__*___*___*__*___*__*___*___* 0.000 0.9021 0 <--> 10. 0 <--> 10. Sensitivity, Optimal Sampling Analysis Section For kel Max for line (A) Cp is 12.26 at 5.000 Note 3 Max 12.26 | AAAAAAAAAAAAAAAAAAA | AAAA AAAAA | AAA AAA | AA AAA | AA AAAA | AA AAAA | AA AAAA | A AA | AA AAA | A AAA | A AA | A | A | A | A | A | A | A | A | | A | A | | A | A | | A | A | | A | | A | | A | A | | A | | |A------------------------------------------------------------------------------ Min 0.000 0 10.00 For V Max for line (A) Cp is 0.4444 at 0.000 Note 3 Max 0.4444 |AA | A | A | A | A | AA | A | AA | A | A | AA | A | AA | A | AA | AA | AA | AA | AAA | AA | AAA | AA | AAA | AAA | AAA | AA | AAA | AAAA | AAAA | AAAA | AAAAA | AAAA | AAAAAAA | AAAAAA | | | | | |------------------------------------------------------------------------------- Min 0.000 0 10.00
This approach and result are essentially the same as for the graphical approach shown earlier.
Boomer Batch File
4 wls,bayes,sim,irwls,sim+error,grid Note 1
1 Screen, diskfile
f2121kelVka
1 Parameter type
Dose
100.0 Parameter value
0 Fixed,adjust,depend1,depend2
1 To
0 F-dependence ?
0 happy or not
2 Parameter type
ka
1.5000 Parameter value
1 Fixed,adjust,depend1,depend2 Note 2
1.49999
1.50001
2
0.01
2 To
1 From
0 happy or not
2 Parameter type
kel
0.2000 Parameter value
1 Fixed,adjust,depend1,depend2 Note 2
0.19999
0.20001
2
0.01
0 To
2 From
0 happy or not
18 Parameter type
V
15.00 Parameter value
1 Fixed,adjust,depend1,depend2 Note 2
14.999
15.001
2
0.01
1 To
Cp
2 From
0 happy or not
-1 Parameter type
2 Integration method
0.000 Relative error
0.000 Absolute error
Simulation kel varying
1 Data from disk or keyboard
0.000 X value
0.000 Y value
1.000 X value
0.000 Y value
2.000 X value
0.000 Y value
3.000 X value
0.000 Y value
4.000 X value
0.000 Y value
5.000 X value
0.000 Y value
6.000 X value
0.000 Y value
7.000 X value
0.000 Y value
8.000 X value
0.000 Y value
9.000 X value
0.000 Y value
10.00 X value
0.000 Y value
-1.000 X value
0 Accept, correct, delete, insert, of
0 Continue or save data
0 Error type for line
0 Weight type Note 3
0 AUC line number
10 Continue,save,plot,supplemental,sen Note 4
-1 wls,bayes,sim,irwls,sim+error,grid
Note 1 Select 'Simulation with random error or sensitivity analysis'
Note 2 Set parameters to be adjustable. Enter 'known' parameter values and set close upper and lower limits
Note 3 Select equal weight. Other weighting is possible but interpretation is curious
Note 4
Select option 10 for graphs and sensitivity
The output of this run is shown in Figure 21.4.4.
** FINAL OUTPUT FROM Boomer (v3.4.7) ** 16 February 2021 --- 12:06:23 pm Title: Simulation kel varying Input: From f2121kelvka.BAT Output: To f2121kelVka.OUT Data for Cp came from keyboard (or ?.BAT) Fitting algorithm: Simulation with Error Weighting for Cp by Equal weight Note 1 Numerical integration method: 2) Fehlberg RKF45 with 2 de(s) With relative error 0.1000E-03 With absolute error 0.1000E-03 This simulation took 0.1000E-01 seconds # Name Value Low Original High 1) ka 1.5000 1.50 1.5 1.5 Note 2 2) kel 0.20000 0.200 0.20 0.20 3) V 15.000 15.0 15. 15. Model and Parameter Definition # Name Value Type From To Dep Start Stop 1) Dose = 100.0 1 0 1 0 0 0 2) ka = 1.500 2 1 2 0 0 0 3) kel = 0.2000 2 2 0 0 0 0 4) V = 15.00 18 2 1 0 0 0 Data for Cp :- DATA # Time Observed Calculated (Weight) Weighted residual 1 0.000 0.00000 0.00000 0.00000 0.00000 2 1.000 0.00000 4.58151 1.00000 0.00000 3 2.000 0.00000 4.77330 1.00000 0.00000 4 3.000 0.00000 4.13613 1.00000 0.00000 5 4.000 0.00000 3.43726 1.00000 0.00000 6 5.000 0.00000 2.82554 1.00000 0.00000 7 6.000 0.00000 2.31588 1.00000 0.00000 8 7.000 0.00000 1.89665 1.00000 0.00000 9 8.000 0.00000 1.55296 1.00000 0.00000 10 9.000 0.00000 1.27148 1.00000 0.00000 11 10.00 0.00000 1.04101 1.00000 0.00000 Plots of observed (*) and calculated values (+) versus time for Cp. Superimposed points (X) 4.773 Linear 4.773 Semi-log | + | + | | + | + | | | + | | | + | | | | | + | | | + | | | | | + | | | + | | | | | + | + | | | | | | + | + | | | + | | | | + | + | + | | | | | | | + | | | | |X * * * * * * * * * * | + |_____________________________________ |X__*___*__*___*___*__*___*__*___*___* 0.000 1.041 0 <--> 10. 0 <--> 10. Sensitivity, Optimal Sampling Analysis Section For ka Max for line (A) Cp is -1.498 at 0.6000 Note 3 Max 0.2804 | AAAAAAAAAAAAAAAAAAAA | AA AAAAAAAAAA | AA AAAAAAAAAAA | A AAAAAAAAAAAA | A | AA |A------------------A----------------------------------------------------------- | | A | A | A | | A | A | | A | | A | A | A | | A | | | A | | A | A | A | | | A | | A A | | A | A | A | A A | A Min -1.498 0 10.00 For kel Max for line (A) Cp is 12.13 at 5.800 Note 3 Max 12.13 | AAAAAAAAAAAAAAAAA | AAA AAAAA | AAA AAAAA | AA AAAA | AA AAAA | AA AAA | A AAA | AA AA | A A | A | AA | A | A | A | A | A | A | A | A | A | | A | A | A | A | | A | A | A | | A | A | A | A | A | | AA | A | AA |A------------------------------------------------------------------------------ Min 0.000 0 10.00 For V Max for line (A) Cp is 0.3259 at 1.600 Note 3 Max 0.3259 | AAAAAAA | A A | A AA | A AA | AA | A AA | A | A AA | AA | A AA | A | A | A AA | AA | AA | AA | A AAA | AA | AAA | A | A AAA | AA | AA | AAA | AA | A AAA | AAA | AAA | AAAA | AAAA | AAAA | A | | | | | | | |A------------------------------------------------------------------------------ Min 0.000 0 10.00
Note 1 Equal weight selected
Note 2 Parameter values constrained at specified values
Note 3 Best time for ka is 0.6 hr, for kel is 5.8 hr and 1.6 hr for V. The resolution of this calculation is 1/100 the maximum time, here 0.1 hr.
This approach and result are essentially the same as for the graphical approach shown earlier.
Material on this website should be used for Educational or Self-Study Purposes Only
Copyright © 2001 - 2025 David W. A. Bourne (david@boomer.org)
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