| Time (hr) | Cp (mg/L) |
| 0.5 | 2.57 |
| 1 | 2.24 |
| 2 | 1.85 |
| 3 | 1.58 |
| 6 | 0.93 |
| 9 | 0.5 |
There is more information (which may help - it may be out of date) as part of an earlier homework set.
Assuming you have the program on your hard drive, double-click on the program icon (Windows or earlier Macintosh) or type boomer at the prompt (Macintosh OS X). You will see something like:
Boomer v3.3.2
Ref: Comput.Meth.Prog.Biomed.,29 (1989) 191-195
David W.A. Bourne
OU College of Pharmacy
1110 N.Stonewall Ave.
Oklahoma City, OK 73117-1223
U.S.A.
Copyright 1986-2006 D.W.A. Bourne
See http://www.boomer.org or email david@boomer.org for more info
Based on the original MULTI by K. Yamaoka, et.al.
J. Pharmacobio-Dyn., 4,879 (1981); ibid, 6,595 (1983); ibid, 8,246 (1985)
DATA ENTRY
0) From KEYBOARD
1) From .BAT file -1) From .BAT file (with restart)
2) From KEYBOARD creating .BAT file
3) From .BAT file (quiet mode) -3) From .BAT file (quiet mode-with restart)
4) to enter data only
5) to calculate AUC from a .DAT file
-8) Shareware Registration Information
-9) to quit
Enter choice (0-5, -1, -3, -8 or -9)
Enter choice (0-5, -1, -3, -8 or -9) 0
METHOD OF ANALYSIS
0) Normal fitting
1) Bayesian
2) Simulation only
3) Iterative Reweighted Least Squares
4) Simulation with random error
5) Grid Search
-3) To run random number test subroutine
-2) To close (or open) .BAT file
-1) To finish
Enter choice (-3 to 5) 0
Where do you want the output?
0) Terminal screen
1) Disk file
Enter choice (0-2) 0
MODEL Definition and Parameter Entry * Allowed Parameter Types *
-3) display choices -2) display parameters -1) to finish entry
0) Time interrupt 1) Dose/initial amount 2) First order rate
3) Zero order 4-5) Vm and Km of Michaelis-Menten
6) Added constant 7) Kappa-Reciprocal volume
8-10) C = a * EXP(-b * (X-c))
11-13) Emax (Hill) Eq with Ec(50%) & S term 14) Second order rate
15-17) Physiological Model Parameters (Q, V, and R)
18) Apparent volume of distribution 19) Dummy parameter for double dependence
20-22) C = a * SIN(2 * pi * (X - c)/b)
Special Functions for First-order Rate Constants
23-24) k = a * X + b 25-27) k = a * EXP(-b * (X - c))
28-30) k = a * SIN(2 * pi * (X - c)/b)
31,32-33) dAt/dt = - k * V * Cf (Saturable Protein Binding)
34-36) k * (1 - Imax * C/(IC(50%) + C)) Inhibition 0 or 1st order
37-39) k * (1 + Smax * C/(SC(50%) + C)) Stimulation 0 or 1st order
40) Uniform [-1 to 1] and 41) Normal [-3 to 3] Probability
42) Switch parameter 43) Clone component
Enter type# for parameter 1 (-3 to 43) 1
Enter parameter name Dose
Enter Dose value 100
0) fixed, 1) adjustable, 2) single dependence
or 3) double dependence 0
Enter component to receive dose 1
Input summary for Dose (type 1)
Fixed value is 100.0
Dose/initial amount added to 1
Enter 0 if happy with input, 1 if not, 2 to start over 0
Enter type# for parameter 2 (-3 to 43)
enter -3 to see choices Enter -1 to exit this section 2
Enter parameter name Rate Constant
Enter Rate Constant value 0.2
0) fixed, 1) adjustable, 2) single dependence
or 3) double dependence 1
Enter lower limit 0
Enter upper limit 5
Enter component to receive flux 0
Enter component to lose flux 1
Input summary for Rate Constant (type 2)
Initial value .2000 float between .000 and 5.000
Transfer from 1 to 0
Enter 0 if happy with input, 1 if not, 2 to start over 0
Enter type# for parameter 3 (-3 to 43)
enter -3 to see choices Enter -1 to exit this section 18
Enter parameter name Apparent Volume
Enter Apparent Volume value 40
0) fixed, 1) adjustable, 2) single dependence
or 3) double dependence 1
Enter lower limit 1
Enter upper limit 200
Enter data set (line) number 1
Enter line description [Drug]
Enter component number (0 for obs x) 1
Input summary for Apparent Volume (type 18)
Initial value 40.00 float between 1.000 and 200.0
Component 1 added to line 1
Enter 0 if happy with input, 1 if not, 2 to start over 0
Enter type# for parameter 4 (-3 to 43)
enter -3 to see choices Enter -1 to exit this section -1
Method of Numerical Integration
0) Classical 4th order Runge-Kutta
1) Runge-Kutta-Gill
2) Fehlberg RKF45
3) Adams Predictor-Corrector with DIFSUB
4) Gears method for stiff equations with PEDERV
5) Gears method without PEDERV
Enter choice (0-5) 2
Enter Relative error term for
Numerical integration (0.0001) 0
Enter Absolute error term for
Numerical integration (0.0001) 0
FITTING METHODS
0) Gauss-Newton
1) Damping Gauss-Newton
2) Marquardt
3) Simplex
4) Simplex->Damping GN
Enter Choice (0-4) 4
Enter PC for convergence (0.00001) 0
Enter description for this analysis: Homework #1 Problem Number 3400658032
Enter data from
0) Disk file 2) ...including weights
1) Keyboard 3) ...including weights
Enter Choice (0-3) 1
Enter data for [Drug]
Enter x-value (time) = -1 to finish data entry
X-value (time) 0.5
Y-value (concentration) 2.57
X-value (time) 1
Y-value (concentration) 2.24
X-value (time) 2
Y-value (concentration) 1.85
X-value (time) 3
Y-value (concentration) 1.58
X-value (time) 6
Y-value (concentration) 0.93
X-value (time) 9
Y-value (concentration) 0.5
X-value (time) -1
Data for [Drug]
DATA # Time Concentration
1 0.5 2.57
2 1 2.24
3 2 1.85
4 3 1.58
5 6 0.93
6 9 0.5
Do you want to
0) Accept data
1) Correct data point
2) Delete data point
3) Insert new data point
4) Add offset to x-value
Enter choice (0-3) 0
Save Observed Data to Disk Module
Data for [Drug]
Select FORMAT for x-value
0) Don't save data
1) G14.1 2) G14.2
3) G14.3 4) G14.4
5) G14.5 6) G14.6
7) F14.0 8) F14.1
9) F14.2 10) F14.3
11) F14.4 12) F14.5
13) F14.6
Enter choice (0-13) 0
Weighting function entry for [Drug]
0) Equal weights
1) Weight by 1/Cp(i)
2) Weight by 1/Cp(i)^2
3) Weight by 1/a*Cp(i)^b
4) Weight by 1/(a + b*Cp(i)^c)
5) Weight by 1/((a+b*Cp(i)^c)*d^(tn-ti))
Data weight as a function of Cp(Obs)
Enter choice (0-5) 2
Time Concentration Weight
0.5 2.57 0.1514
1 2.24 0.1993
2 1.85 0.2922
3 1.58 0.4006
6 0.93 1.1562
9 0.5 4
.2000 40.00
WSS -> 4.130
.1676 40.69
WSS -> 3.922
.1672 34.53
WSS -> 3.594
Progressive values of WSS
Loop 1 -
1> 4.130 2> 3.922 3> 3.594
Loop 2 -
1> 2.233 2> 3.922 3> 3.594
Loop 3 -
1> 2.233 2> 1.612 3> 3.594
Loop 4 -
1> 2.233 2> 1.612 3> 1.256
........ extra stuff here
Loop 37 -
1> .4881E-01 2> .4881E-01 3> .4881E-01
Loop 38 -
1> .4881E-01 2> .4881E-01 3> .4881E-01
Loop 39 -
1> .4881E-01 2> .4881E-01 3> .4881E-01
Loop 40 -
1> .4881E-01 2> .4881E-01 3> .4881E-01
........ extra stuff here including your answers
Calculation of AUC and AUMC section
0) Exit this section
1) [Drug]
Enter line # for required AUC (0- 1) 0
GRAPH OUTPUT
0) Continue without graphical output
1) Save data on disk for later graphing
2) Produce a printer plot now
3) Save for later and print now
Enter choice (0-3) 2
METHOD OF ANALYSIS
0) Normal fitting
1) Bayesian
2) Simulation only
3) Iterative Reweighted Least Squares
4) Simulation with random error
5) Grid Search
-3) To run random number test subroutine
-2) To close (or open) .BAT file
-1) To finish
Before you enter the final '-1' in the next step scroll back to record the answers, i.e. Rate constant, Apparent Volume and WSS values
Enter choice (-3 to 5) -1 Normal FinishPrint out the ouput from this analysis using a Courier 9 point font. Note the best fit or final values for the rate constant, the apparent volume and the WSS for entry on this website.
Material on this website should be used for Educational or Self-Study Purposes Only
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