Figure VIII-5, Linear Plot of Cp versus Time with ka = 3, 0.6, or 0.125 hr sup>-1
Before going on to calculate the parameters ka, kel, and F from data provided we can look at the effect different values of F and ka have on the plasma concentration versus time curve.
tpeak = 1, 2.75, 6.25 hour.
Notice that with higher values of ka the peak plasma concentrations are higher and earlier.
Figure VIII-6, Linear Plot of Cp versus Time with F = 1, 0.66, or 0.33
Changing F values is equivalent to changing the dose. Thus the higher the F value the higher the concentration values at each time point. Since the values of kel and ka are unchanged the time of peak plasma concentration is unchanged.
Thus, tpeak = 1, 1, and 1 hour. The same in each case.
Copyright 2002 David W.A. Bourne