Laplace Transform Examples

One Compartment Models

IV Bolus Dose Administration

Derive the Integrated Equation for the Amount of Metabolite in the Body, X3

The Model

Model with X3 highlighted

Component of Interest - Metabolite in the Body

Step 1. Write the differential equations

Differential equation for X1

Differential equation for X3

Step 2. Transform into the Laplace domain

Equation for X1 in the Laplace domain

and

Equation for X3 in the Laplace domain

Step 3. Rearrange and solve for L(X3)

Equation for Laplace of X1

and

Equation for Laplace of X3

substituting the first term (L(X1)) into the second equation gives

Equation for Laplace of X3

Step 4. Back transform to produce the integrated equation for X3

Integrated equation for X3

using Laplace tables for the back transform

Integrated equation for X3

using the Fingerprint method for the back transform

Back to the Problem Page


Return to Index


return to the Course index


This page was last modified: Sunday, 28th Jul 2024 at 4:43 pm


Privacy Statement - 25 May 2018

iBook and pdf versions of this material and other PK material is available

Copyright © 2001-2022 David W. A. Bourne (david@boomer.org)