Laplace Transform Examples

One Compartment Models

Oral Dose Administration

Derive the Integrated Equation for the Amount of Drug in Urine, X2

The Model

Model with X2 highlighted

Component of Interest - Drug in Urine

Step 1. Write the differential equations

Differential equation for X5

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Differential equation for X1

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Differential equation for X2

Step 2. Transform into the Laplace domain

X5 in the Laplace domain

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X1 in the Laplace domain

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Equation for X2 in the Laplace domain

Step 3. Rearrange and solve for L(X2)

X5 in the s domain

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X1 in the s domain

substituting the first term (L(X5)) into the second equation gives

X1 in the s domain

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X2 in the s domain

substituting the second term (L(X1)) into the third equation gives

X2 in the s domain

Step 4. Back transform to produce the integrated equation for X2

Integrated equation for X2

using Laplace tables for the back transform

Integrated equation for X2

using the Fingerprint method for the back transform

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