# Chapter 4

# One Compartment IV Bolus

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## IV Bolus - Example 1

Question: What is the concentration of drug 0, 2 and 4 hours after a dose of 500 mg. Known pharmacokinetic parameters are apparent volume of distribution, V is 30 liter and the elimination rate constant, kel is 0.2 hr^{-1}
Answer: Use Equation 4.11.1 to calculate the required concentrations

**Equation 4.11.1 Concentration as a Function of Time**

Thus:

**Try your own calculation**

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