# Chapter 4

# One Compartment IV Bolus

return to the Course index

previous | next

## IV Bolus - Example 2

We can also calculate the pharmacokinetic parameters kel and V if we know the dose given and the plasma concentrations at two (or more) times after an IV bolus administration. This time we will use Equation 4.12.1

**Equation 4.12.1 Kel calculated from Two Concentration Values**

Question: If Cp^{2 hours} is 4.5 mg/liter and Cp^{6 hours} is 3.7 mg/liter after a 400 mg IV bolus dose what are the values of kel and V.

Now using either the 2 hour or the 6 hour data point calculate the concentration at time zero.

And now

**Equation 4.12.2 V from Dose and Cp**^{0}

and

**Equation 4.12.3 Clearance from kel and V**

**Try your own calculation**

Answers

**References**
- Winter, M.E. 1988
**Basic Clinical Pharmacokinetics**, 2nd. ed., Applied Therapeutics, Vancouver, WA ISBN 0915486083

return to the Course index

This page was last modified: Wednesday, 27th Sep 2017 at 5:18 pm

Privacy Statement - 25 May 2018

Material on this website should be used for Educational or Self-Study Purposes Only

iBook and pdf versions of this material and other PK material is available

Copyright © 2001-2019 David W. A. Bourne (david@boomer.org)