# Chapter 4

# One Compartment IV Bolus

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## IV Bolus - Example 2

We can also calculate the pharmacokinetic parameters kel and V if we know the dose given and the plasma concentrations at two (or more) times after an IV bolus administration. This time we will use Equation 4.12.1

**Equation 4.12.1 Kel calculated from Two Concentration Values**

Question: If Cp^{2 hours} is 4.5 mg/liter and Cp^{6 hours} is 3.7 mg/liter after a 400 mg IV bolus dose what are the values of kel and V.

Now using either the 2 hour or the 6 hour data point calculate the concentration at time zero.

And now

**Equation 4.12.2 V from Dose and Cp**^{0}

and

**Equation 4.12.3 Clearance from kel and V**

**Try your own calculation**

Answers

**References**
- Winter, M.E. 1988
**Basic Clinical Pharmacokinetics**, 2nd. ed., Applied Therapeutics, Vancouver, WA ISBN 0915486083

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