# Chapter 4

# One Compartment IV Bolus

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## IV Bolus - Example 4

Question: After an I.V. bolus dose of 500 mg the data collected in Table 4.14.1 were collected. Calculate kel and V.

**Table 4.14.1 Concentration ***versus* Time Data
**Time (hr)** |
1 |
2 |
3 |
4 |
6 |
8 |
10 |

**Cp (mcg/ml)** |
72 |
51 |
33 |
20 |
14 |
9 |
4 |

Plot the data on semi-log graph paper (Figure 4.14.1) and determine Cp^{1}, Cp^{2}, t1^{} and t^{2}.

**Figure 4.14.1 Plot of Cp ***versus* Time on Semi-log Graph Paper After an I.V. Bolus Dose of 500 mg.

and

**Figure 4.14.2 V from dose and Cp**^{0}

and

**Equation 4.12.3 Clearance from kel and V**

**Try your own calculation**

**Figure 4.5.1 Linear plot of ln(Cp) ***versus* time

Click on the figure to view the interactive graph

**For practice** you can plot these data collected after an IV bolus dose and estimate pharmacokinetic parameters.

Student Objectives for this Chapter

Chapter 4 Crossword Puzzle
and
key

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