Chapter 4

One Compartment IV Bolus

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IV Bolus - Example 4

Question: After an I.V. bolus dose of 500 mg the data collected in Table 4.14.1 were collected. Calculate kel and V.

Table 4.14.1 Concentration versus Time Data
Time (hr) 1 2 3 4 6 8 10
Cp (mcg/ml) 72 51 33 20 14 9 4

Plot the data on semi-log graph paper (Figure 4.14.1) and determine Cp1, Cp2, t1 and t2.

Figure 4.14.1 Plot of Cp versus Time on Semi-log Graph Paper After an I.V. Bolus Dose of 500 mg.



Figure 4.14.2 V from dose and Cp0


Equation 4.12.3 Clearance from kel and V

Try your own calculation

Calculator 4.14.1 Calculate Parameter Values from Two Data Points from a Line drawn through Data Collected after an IV Bolus

IV Bolus Dose:
First concentration:
Time of first Cp value:
Second concentration:
Time of second Cp value:
kel is:
t1/2 is:
Cp0 is:
V is:
and Total Body Clearance is:

If you get the Error Message Value is not a numeric literal or NaN this probably means that one of the required parameter fields is empty or a value is inappropriate.

For practice you can plot these data collected after an IV bolus dose and estimate pharmacokinetic parameters.

Student Objectives for this Chapter

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