Chapter 3 Biopharmaceutics and Pharmacokinetic Introduction

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Aspirin Elimination

redrawn from Levy, 1965

Figure 3.26.1 Slide of aspirin plasma concentration as a function of time after 0.25, 1 or 2g. At higher doses the metabolism of aspirin is reduced by saturation. The elimination rate constant (as represented by the slope) is reduced.

References

Levy, G. 1965 J. Pharm. Sci., 54, p959

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